heme b

Three steps

• protein polypeptide chainReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. PROTEIN_BS

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 5 morecytosol, mitochondrial matrix

• CHEBI:16633Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by COX10, COX15, RSAD2mitochondrial matrix

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Heme Oxygenase 1
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

  Catalysed by HMOX1, HMOX2, ADI1cytosol

• (S)-2-hydroxyglutarateReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by COX10, COX15, L2HGDHmitochondrial matrix

• CHEBI:16856Reach from here →
  1. Heme Oxygenase 1
  2. Bilirubin:NAD+ oxidoreductase
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, BLVRB, BLVRA and 2 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• L-isoleucineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• CHEBI:17203Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• dehydroascorbic acidReach from here →
  1. Heme Oxygenase 1
  2. Fe(II):oxygen oxidoreductase
  3. cytochrome b reductase (ascorbate)

  Catalysed by HMOX1, HMOX2, CP, FTH1 and 4 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by COX10, COX15, CDK5RAP1mitochondrial matrixOne of 4 routes

• L-cysteineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 11 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by COX10, COX15, DIO1mitochondrial matrix

• 3,3'-diiodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by COX10, COX15, DIO1mitochondrial matrixOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix

• CHEBI:17895Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 8 morecytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• CHEBI:18095Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. Transport of Hydroxy-Proline

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular space

• 2-aminoisobutanoateReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by COX10, COX15, DIO3mitochondrial matrix

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix

• (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronosideReach from here →
  1. Heme Oxygenase 1
  2. (4Z,15Z)-bilirubin IXalpha + NADP(+) = biliverdin IXalpha + NADPH + H(+)
  3. (4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP

  Catalysed by HMOX1, HMOX2, BLVRA, UGT1A1cytosol

• (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronosideReach from here →
  1. Heme Oxygenase 1
  2. (4Z,15Z)-bilirubin IXalpha + NADP(+) = biliverdin IXalpha + NADPH + H(+)
  3. (4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP

  Catalysed by HMOX1, HMOX2, BLVRA, UGT1A1cytosol

• 3-iodothyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

• 3-iodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrixOne of 2 routes

• 3'-iodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

• L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by COX10, COX15, DIO3mitochondrial matrix

• thyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by COX10, COX15, DIO3mitochondrial matrix

• 3'-iodothyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrixOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by COX10, COX15, DIO3mitochondrial matrix

• 3,3',5'-triiodothyronamineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by COX10, COX15, DIO3mitochondrial matrix

• pyridoxine 5'-phosphateReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix

• chlorine(.)Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• hydrogenselenideReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by COX10, COX15, SCLYmitochondrial matrix

• L-aspartateReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix

• formic acidReach from here →
  1. Heme Oxygenase 1
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. acireductone dioxygenase

  Catalysed by HMOX1, HMOX2, ADI1cytosolOne of 2 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. Heme Oxygenase 1
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. Acireductone Dixoygenase 1

  Catalysed by HMOX1, HMOX2, ADI1cytosol

• tetra-mu3-sulfido-tetrairon(2+)Reach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. Synthesis of 4Fe4S from 2Fe2S

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 11 morecytosol, mitochondrial matrix

• D-cysteineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• 25-hydroxycholesterolReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by COX10, COX15, CH25Hmitochondrial matrix

• L-ornithineReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 6 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• 3-(methylsulfanyl)propanoateReach from here →
  1. Heme Oxygenase 1
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

  Catalysed by HMOX1, HMOX2, ADI1cytosol

• gamma-Glu-AlaReach from here →
  1. Heme Oxygenase 1
  2. De novo synthesis of 2Fe2S
  3. gamma-glutamyltransferase (alanine)

  Catalysed by HMOX1, HMOX2, NDUFAB1, FDXR and 11 morecytosol, mitochondrial matrix, extracellular space

• all-trans-13,14-dihydroretinolReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by COX10, COX15, RETSATmitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by COX10, COX15, DIO1, DIO2mitochondrial matrix

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. farnesyl-PP[m] + H2O[m] + heme[m] = PPi[m] + Fe(II)-heme o[m]
  2. Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by COX10, COX15, DIO1, DIO3mitochondrial matrix