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Reach

glutathione disulfide

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

410 compounds within 3 steps: 6 in 1, 99 in 2, 305 in 3

Does it reach a compound?

Two steps

(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by GSR, GPX1, GPX4
thromboxane B2Reach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes
an S-substituted glutathioneReach from here →
1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by GSR, GSTT4, GSTA4, GSTZ1 and 20 moreOne of 2 routes
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by GSR, GPX1, GSTA1, GPX2 and 1 more
taurochenodeoxycholateReach from here →
1. Glutathione: 15-HPETE oxidoreductase
2. solute carrier organic anion transporter (GSH)
Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, extracellular spaceOne of 3 routes

Three steps

(S)-carnitineReach from here →
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes
CHEBI:1146900Reach from here →

Page 3 of 9

Catalysed by GPX5, GPX1, GPX2, GPX3 and 38 more

cytosol, extracellular space

One of 7 routes

2-hydroxybutyric acidReach from here →

cystine to cysteine conversion
L-cystine thiocysteine-lyase (deaminating
transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by CTH, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

N(omega)-methyl-L-arginineReach from here →

cystine to cysteine conversion
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by SLC7A9, SLC3A1, AGXT2cytosol, extracellular spaceOne of 3 routes

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

AReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and thyroxine (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular spaceOne of 11 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 13 morecytosol, extracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 13 morecytosol, extracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 10 morecytosol, extracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol, extracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

a quinoneReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

Catalysed by GSR, SQOR, CYC1, UQCRFS1outer side of the membraneOne of 7 routes

pregnenolone sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
Steryl-Sulfatase

Catalysed by TSTD1, STScytosol, Golgi apparatusOne of 2 routes

androsterone 3alpha-sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
steroid sulfatase (androsterone sulfate)

Catalysed by TSTD1, STScytosolOne of 3 routes

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

prostaglandin J2Reach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular spaceOne of 4 routes

dopamine 3-O-sulfateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of dopamine and GSH (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 11 morecytosol, extracellular space

dopamine 4-O-sulfateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of dopamine and GSH (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol, extracellular spaceOne of 2 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
glutathione = L-cysteinylglycine + 5-oxo-L-proline
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by GSR, CHAC2, CHAC1, GGACT

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

hypothiocyanous acidReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
thiosulfate:cyanide sulfurtranserase
Dihydrolipoyl Dehydrogenase

Catalysed by TSTD1, MPST, TST, LPOmitochondrial matrix, extracellular spaceOne of 4 routes

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

N-(9Z-octadecenoyl)-L-leucineReach from here →

cystine to cysteine conversion
Transport of L-Cystine (L-Leucine antiport) by B0, +At Transporter
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by SLC7A9, SLC3A1, PM20D1cytosol, extracellular space

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular spaceOne of 2 routes

cholesterol sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
Steryl-Sulfatase

Catalysed by TSTD1, STScytosol, Golgi apparatusOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, extracellular space

5alpha-dihydrotestosterone sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by TSTD1, STScytosolOne of 3 routes

acetoacetateReach from here →

cystine to cysteine conversion
L-cystine thiocysteine-lyase (deaminating
transport of acetoacetate and pyruvate (cytosol to mitochondria)

Catalysed by CTHcytosol, mitochondrial matrixOne of 4 routes

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

Glutathione: 15-HPETE oxidoreductase
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by GPX5, GPX1, GPX2, GPX3 and 31 morecytosol, extracellular space

(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by GSR, PTGES, MGST3, GPX1 and 4 more

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

Glutathione: 15-HPETE oxidoreductase
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 12 morecytosol

an aryl sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
an aryl sulfate + H2O = a phenol + sulfate + H(+)

Catalysed by TSTD1, ARSL, ARSF, ARSK and 3 morecytosol

an organic moleculeReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by GSR, CP, PRDX6, CYP2D7 and 24 more

N-octanoyl-(2S)-hydroxyglycineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GSR, CLIC1, GSTO1, GSTO2 and 1 more

N-decanoyl-(2S)-hydroxyglycineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GSR, CLIC1, GSTO1, GSTO2 and 1 more

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GSR, CLIC1, GSTO1, GSTO2 and 1 more

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GSR, CLIC1, GSTO1, GSTO2 and 1 more

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by GSR, CLIC1, GSTO1, GSTO2 and 1 more