2-methyl-3-oxobutanoyl-CoA

Three steps

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosol

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Utilized Transport

  Catalysed by HADHA, ACAA2, HADHBmitochondrial matrix, cytosol, endoplasmic reticulum

• CHEBI:27540Reach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 6 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosol, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Carnitine Transport by Atb0

  Catalysed by HADHA, ACAA2, HADHB, SLC6A14mitochondrial matrix, cytosol, extracellular space

• acetateReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. transport of acetate and propanoate (cytosol to extracellular)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. transport of formate and propanoate (cytosol to extracellular)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. transport of butyrate and propanoate (cytosol to extracellular)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Utilized Transport

  Catalysed by HADHA, ACAA2, HADHBmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (9Z)-hexadecenoateReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Utilized Transport

  Catalysed by HADHA, ACAA2, HADHBmitochondrial matrix, cytosol, endoplasmic reticulumOne of 6 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Utilized Transport

  Catalysed by HADHA, ACAA2, HADHBmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• glyoxylateReach from here →
  1. propanoyl-CoA + acetyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by ACAT1, CLYBL

• (S)-lactic acidReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. transport of L-lactate and propanoate (cytosol to extracellular)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 6 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• taurineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• glycineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosolOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosolOne of 4 routes

• 3'-dephospho-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by HADHA, ACAA2, HADHB, ACOT7mitochondrial matrix, cytosolOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 6 moremitochondrial matrix, cytosolOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosolOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosolOne of 20 routes

• phytanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7mitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 7 moremitochondrial matrix, cytosolOne of 15 routes

• O-acetyl-(R)-carnitineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Active Transport
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by HADHA, ACAA2, HADHB, CPT1A and 2 moremitochondrial matrix, cytosolOne of 9 routes

• sphing-4-enineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 4 moremitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. propanoyl-CoA + acetyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA
  2. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  3. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by ACAT1, ACOT8, ACAA2, ACOT9 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-alanineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7mitochondrial matrix, cytosol

• L-asparagineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosol

• L,L-cystathionineReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 1 moremitochondrial matrix, cytosol

• an acyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 4 moremitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7mitochondrial matrix, cytosolOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. propanoyl-CoA + acetyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA
  2. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by ACAT1, ACOT8, ACAA2, ACOT9 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• decanoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 3 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 8 moremitochondrial matrix, cytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase
  2. Propanoyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by HADHA, ACAA2, HADHB, ACOT7 and 2 moremitochondrial matrix, cytosol