tetra-mu3-sulfido-tetrairon(2+)

Three steps

• glycocholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• cholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• D-aspartateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:30249Reach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, extracellular space, cytosol

• oxalateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. lipoyl synthase
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• maleateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 4 routes

• (S)-dihydroorotateReach from here →
  1. lipoyl synthase
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• an alcoholReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-lysineReach from here →
  1. lipoyl synthase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. lipoyl synthase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. lipoyl synthase
  2. transport of isoleucine and methionine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• D-cysteineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 10 routes

• an organic disulfideReach from here →
  1. lipoyl synthase
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

• 5-aminolevulinateReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. lipoyl synthase
  2. transport of isoleucine and methionine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. lipoyl synthase
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• taurocholateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• glycochenodeoxycholic acidReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 12 routes

• glycolithocholic acidReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 25-hydroxycholesterolReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• tert-butanolReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. lipoyl synthase
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. gamma-glutamyltransferase (alanine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 15 moremitochondrial matrix, extracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• taurineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 4 routes

• a thioesterReach from here →
  1. lipoyl synthase
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. a thioester + H2O = a thiol + a carboxylate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• all-trans-13,14-dihydroretinolReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• 3,3',5-triiodo-L-thyronineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. lipoyl synthase
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• deoxyhemoglobinReach from here →
  1. lipoyl synthase
  2. Ferrochelatase, Mitochondrial
  3. globin to hemoglobin conversion

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosol

• 3,3',5'-triiodo-L-thyronineReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix

• (R)-methylmalonyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 7 routes