all-trans-retinyl hexadecanoate

Three steps

• isovaleryl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 10 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 12 routes

• oleoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosolOne of 43 routes

• a 1-hexadecanoyl-2-acylglycerolReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 11 more

• an hexadecanoyl-acylglycerolReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 11 more

• 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 11 more

• CHEBI:15650Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 34 morecytosolOne of 2 routes

• betaine aldehydeReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. choline + A = betaine aldehyde + AH2

  Catalysed by PNLIP, PNPLA4, LIPE, RETSAT and 1 more

• CHEBI:15727Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 3 morecytosol

• CHEBI:15746Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 4 morecytosolOne of 2 routes

• hexadecanoic acidReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]

  Catalysed by PNLIP, PNPLA4, LIPE, NAAA and 3 morenucleus, cytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. Lecithin Retinol Acyltransferase
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by PNLIP, PNPLA4, LIPE, LRAT and 4 morecytosol

• cholesterolReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by PNLIP, PNPLA4, LIPE, NAAA and 4 more

• hexadecan-1-olReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. hexadecanoyl-CoA + 2 NADPH + 2 H(+) = hexadecan-1-ol + 2 NADP(+) + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 12 more

• oxaloacetateReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. (R)-malate + A = oxaloacetate + AH2

  Catalysed by PNLIP, PNPLA4, LIPE, RETSAT and 1 moreOne of 2 routes

• formaldehydeReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by PNLIP, PNPLA4, LIPE, RETSAT and 2 moreOne of 3 routes

• sn-glycerol 3-phosphocholineReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. Lecithin Retinol Acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by PNLIP, PNPLA4, LIPE, LRAT and 10 morecytosolOne of 3 routes

• anilineReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 4 morecytosol

• CHEBI:17312Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosolOne of 2 routes

• a monoacylglycerolReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
  3. a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)

  Catalysed by PNLIP, PNPLA4, LIPE, PNPLA2 and 1 more

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 13 more

• AH2Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. A + NADH + H(+) = AH2 + NAD(+)

  Catalysed by PNLIP, PNPLA4, LIPE, RETSAT and 2 moreOne of 20 routes

• L-cysteineReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by PNLIP, PNPLA4, LIPE, RETSAT and 1 moreOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrix

• CHEBI:17927Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosol

• superoxideReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosol

• 13-cis-retinyl esterReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. retinol binding protein (retinol)
  3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, RBP1 and 2 morecytosol

• 9-cis-retinyl esterReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. retinol binding protein (retinol)
  3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, RBP1 and 2 morecytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 10 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 10 morecytosolOne of 8 routes

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 11 more

• N-acetylcysteine methyl esterReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)

  Catalysed by PNLIP, PNPLA4, LIPE, PPT1

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 8 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 10 morecytosolOne of 5 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-peroxy-docosahexaenoate to DHA conversion

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 2 morecytosol

• CHEBI:28701Reach from here →
  1. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by RPE65, DGAT1, LRAT, AWAT1 and 5 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. Lecithin Retinol Acyltransferase
  3. an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)

  Catalysed by PNLIP, PNPLA4, LIPE, LRAT and 1 morecytosolOne of 3 routes

• (9Z)-octadecenoateReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol
  3. di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)

  Catalysed by PNLIP, PNPLA4, LIPE, PNPLA2 and 2 more

• all-trans-retinoateReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. retinol: NADP+ oxidoreductase
  3. all-trans-retinal + NAD(+) + H2O = all-trans-retinoate + NADH + 2 H(+)

  Catalysed by PNLIP, PNPLA4, LIPE, DHRS3 and 10 morecytosolOne of 2 routes

• fatty acidReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. Lecithin Retinol Acyltransferase
  3. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase

  Catalysed by PNLIP, PNPLA4, LIPE, LRAT and 10 morecytosolOne of 3 routes

• cholesteryl hexadecanoateReach from here →
  1. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA

  Catalysed by PNLIP, PNPLA4, LIPE, SLC27A2 and 11 more