O-hexadecanoyl-(R)-carnitine

Three steps

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by CPT2, CPT1A, FAAHperoxisome, endoplasmic reticulum, cytosol

• (R)-2-hydroxyhexadecanoateReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)
  3. hexadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by CPT2, CPT1A, CPT1B, ACOT7 and 17 more

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT2, CPT1A, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Beta Oxidation of Long Chain Fatty Acid
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by CPT2, CPT1A, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CPT2, CPT1A, CPT1B, LPCAT3 and 2 moreOne of 3 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by CPT2, CPT1A, CPT1B, LPGAT1 and 1 moreOne of 3 routes

• 1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by CPT2, CPT1A, CPT1B, LPCAT3 and 2 moreOne of 3 routes

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, PRDX6 and 7 moreOne of 10 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by CPT2, CPT1A, CPT1B, LPGAT1 and 1 moreOne of 2 routes

• 1-O-alkyl-3-acylglycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by CPT2, CPT1A, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Production of Suberylcarnitine

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• 3-oxo-(11Z)-octadecenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA

  Catalysed by CPT2, CPT1A, SCD, ELOVL6 and 1 moreperoxisome, cytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes

• (13Z)-eicosenoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 8 moreperoxisome, cytosolOne of 6 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. arachidonic acid:oxygen 1-oxidoreductase

  Catalysed by CPT2, CPT1A, CYP1A1, CYP1A2 and 25 moreperoxisome, endoplasmic reticulum, cytosolOne of 3 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, CPT1A, CYP2C9peroxisome, endoplasmic reticulum, cytosol

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, CPT1A, CYP1A1, CYP1A2 and 3 moreperoxisome, endoplasmic reticulum, cytosol

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 2 moreperoxisome, cytosolOne of 4 routes

• tetradecanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 4 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by CPT2, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 1 moreperoxisome, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by CPT2, CPT1A, MOGAT1peroxisome, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT2, CPT1A, LPCAT2, LPCAT1peroxisome, cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, LPCAT4peroxisome, cytosol

• 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Beta Oxidation of Long Chain Fatty Acid
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. fatty-acyl-CoA synthase (N-C18:0CoA)
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by CPT2, CPT1A, LPCAT4peroxisome, cytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, LPGAT1 and 2 moreOne of 2 routes

• a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by CPT2, CPT1A, CPT1B, PRDX6 and 3 more

• 1-O-hexadecylglycerone 3-phosphateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. formate dehydrogenase (palmitoyl-CoA)
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, FAR1, FAR2 and 1 moreperoxisomeOne of 2 routes

• undecanoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by CPT2, CPT1A, CPT1C, CPT1B and 6 moreperoxisome, cytosolOne of 3 routes

• (2E,9Z)-hexadecadienoyl-CoAReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. palmitoyl-CoA desaturase (N-C16:0CoA -> N-C16:1CoA)
  3. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)

  Catalysed by CPT2, CPT1A, SCD, ACADM and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, AGPAT3 and 5 more

• 1,3-dihexadecanoylglycerolReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
  3. 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1,3-dihexadecanoylglycerol + (9Z)-octadecenoate + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, MOGAT3 and 1 more

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by CPT2, CPT1A, ASAH1, ACER2 and 3 moreperoxisome, endoplasmic reticulum, cytosol

• N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by CPT2, CPT1A, CPT1B, PRDX6 and 4 moreOne of 3 routes

• 18-hydroxy-(9Z)-octadecenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT2, CPT1A, CYP4A11, CYP4F11peroxisome, endoplasmic reticulum, cytosol

• N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CPT2, CPT1A, CPT1B, CERS6 and 4 more

• N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CPT2, CPT1A, CPT1B, CERS6 and 3 more

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by CPT2, CPT1A, CPT1B, CERS6 and 4 more

• N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. (4R)-hydroxysphinganine + hexadecanoyl-CoA = N-hexadecanoyl-(4R)-hydroxysphinganine + CoA + H(+)
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by CPT2, CPT1A, CPT1B, CERS6 and 3 more

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)

  Catalysed by CPT2, CPT1A, ABHD12peroxisome, endoplasmic reticulum, cytosol

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by CPT2, CPT1A, PTGS2peroxisome, endoplasmic reticulum, cytosolOne of 2 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by CPT2, CPT1A, PTGS2peroxisome, endoplasmic reticulum, cytosolOne of 2 routes

• (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by CPT2, CPT1A, PTGS2peroxisome, endoplasmic reticulum, cytosol

• 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  2. Utilized Transport
  3. Arachidonate: oxygen 11-oxidoreductase

  Catalysed by CPT2, CPT1A, ALOX12peroxisome, endoplasmic reticulum, cytosolOne of 2 routes