adenosine

Three steps

• L-methionineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 3 routes

• L-tryptophanReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• ADP-D-riboseReach from here →
  1. adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine
  2. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
  3. D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate

  Catalysed by LACC1, PGM2, NUDT5

• L-alanineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 20 routes

• 5-phospho-alpha-D-ribose 1-diphosphateReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. ATP:D-ribose-5-phosphate diphosphotransferase

  Catalysed by PNP, PGM2, PRPS2, PRPS1L1 and 1 morecytosolOne of 2 routes

• L-asparagineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• L-phenylalanineReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• D-ribulose 5-phosphateReach from here →
  1. adenosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. D-ribose-5-phosphate aldose-ketose-isomerase

  Catalysed by PNP, PGM2, RPIAcytosol, endoplasmic reticulumOne of 2 routes

• (2R)-2-phosphoglycerateReach from here →
  1. adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine
  2. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. D-phosphoglycerate 2,3-phosphomutase

  Catalysed by LACC1, PGM2L1, BPGM, PGAM2 and 2 morecytosolOne of 2 routes

• dCDPReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 20 routes

• (3S)-citramalyl-CoAReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by PKM, PKLR, CLYBLcytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by PKM, PKLR, AGXT2cytosol

• dIMPReach from here →
  1. Adenosine aminohydrolase
  2. dIMP + inosine = 2'-deoxyinosine + IMP
  3. dIMP + inosine = 2'-deoxyinosine + IMP

  Catalysed by ADA, ADA2, NT5C2cytosolOne of 2 routes

• dCTPReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 2 routes

• dUTPReach from here →
  1. Adenosine Kinase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by TXN, RRM1, RRM2, RRM2B and 1 morecytosol, mitochondrial matrixOne of 3 routes

• a ribonucleoside 5'-triphosphateReach from here →
  1. Adenosine Kinase
  2. UMP/CMP kinase (dCDP)
  3. 2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)

  Catalysed by DCKcytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by PKM, PKLR, HOGA1cytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by PKM, PKLR, HOGA1cytosol

• thiamine(1+) diphosphateReach from here →
  1. Adenosine Kinase
  2. dADP to dATP conversion
  3. Antiport of thiamine-diphosphate and dATP

  Catalysed by SLC25A19cytosol, mitochondrial matrixOne of 2 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Adenosine Kinase
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by PKM, PKLR, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix