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Proteins/UNIPROT:P45844
Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol..
Function from UniProtKB (P45844), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
40 statements
40 statements · 6 reference databases · Subject: ABCG1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
ATP+CHEBI:1307929+waterADP+CHEBI:1307929+proton+phosphate(3-)
Transported by ABCG8 & ABCG5 or ABCA1 or ABCG1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01911CC BY 4.0Reference data
4 names
Resolves to: ABCG1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38903CC BY 4.0Reference data
cholesterol+ATP(4-)+watercholesterol+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8 or ABCA1 or ABCG1 or ABCA13 or ABCA5 or ABCA3 or ABCG4 or ABCG8 or ABCG5
Reaction pageLeft to rightBalanced
Rhea RHEA:39051CC BY 4.0Reference data
CHEBI:42989+ATP(4-)+waterCHEBI:42989+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCG1
Reaction pageLeft to rightBalanced
Rhea RHEA:39795CC BY 4.0Reference data
an N-(acyl)-sphingosylphosphocholine+ATP(4-)+wateran N-(acyl)-sphingosylphosphocholine+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCG1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:46468CC BY 4.0Reference data