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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:O60240

PLIN1

Protein·UNIPROT:O60240

Open in the graph

Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels..

Function from UniProtKB (O60240), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

PLIN1-related familial partial lipodystrophy has a germline basis in PLIN1DiseaseGenCC HGNC:9076|MONDO:0013478Inferred only

Statements

42 statements

42 statements · 5 reference databases · Subject: PLIN1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways

Search this listOrder

PLIN1 interacts with ABHD5ProteinHetionet hetionet:interacts:51099-5346Inferred only
PLIN1 interacts with PRKACAProteinHetionet hetionet:interacts:5346-5566Inferred only
PLIN1 participates in AdipogenesisPathwayReactome R-HSA-9843745Inferred only
PLIN1 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
PLIN1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PLIN1 participates in Epigenetic regulation by WDR5-containing histone modifying complexesPathwayReactome R-HSA-9917777Inferred only
PLIN1 participates in Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexesPathwayReactome R-HSA-9851695Inferred only
PLIN1 participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
PLIN1 participates in Epigenetic regulation of gene expression by MLL3 and MLL4 complexesPathwayReactome R-HSA-9818564Inferred only
PLIN1 participates in Familial partial lipodystrophyPathwayWikiPathways WP5102Inferred only
PLIN1 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
PLIN1 participates in Lipid metabolism pathwayPathwayWikiPathways WP3965Inferred only

Show the remaining 30

PLIN1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLIN1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLIN1 participates in MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisPathwayReactome R-HSA-9841922Inferred only
PLIN1 participates in NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adiposePathwayReactome R-HSA-9031528Inferred only
PLIN1 participates in NR1H2 and NR1H3-mediated signalingPathwayReactome R-HSA-9024446Inferred only
PLIN1 participates in PPAR signalingPathwayWikiPathways WP3942Inferred only
PLIN1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PLIN1 participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
PLIN1 participates in ThermogenesisPathwayWikiPathways WP4321Inferred only
PLIN1 participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
PLIN1 participates in Transcriptional regulation of white adipocyte differentiationPathwayReactome R-HSA-381340Inferred only
PLIN1 participates in Triglyceride catabolismPathwayReactome R-HSA-163560Inferred only
PLIN1 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
PLIN1 regulates negative regulation of triglyceride catabolic processBiological processgene ontology O60240|GO:0010897Inferred only
ATP2C1 increases the expression of PLIN1ProteinHetionet hetionet:regulates:27032-5346Inferred only
HEXIM1 increases the expression of PLIN1ProteinHetionet hetionet:regulates:10614-5346Inferred only
SYT1 decreases the expression of PLIN1ProteinHetionet hetionet:regulates:6857-5346Inferred only
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
1-O-acyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
1-phosphatidyl-1D-myo-inositol is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
a 1,2-diacyl-sn-glycerol is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
a cholesterol ester is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
a sphingomyelin is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
a triacylglycerol is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
CHEBI:1307929 is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
fatty acid is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
phosphatidyl-L-serine is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only
phosphatidylethanolamine is a substrate of PLIN1CompoundHuman-GEM MAR00031Inferred only

Reactions

1 reaction

0.19a 1,2-diacyl-sn-glycerol+0.0014MAM00511c+0.0024a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+0.00061-O-acyl-sn-glycero-3-phosphocholine(1+)+0.005CHEBI:1307929+0.34a cholesterol ester+0.00081-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine+0.00921,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.0034phosphatidylethanolamine+0.00161-phosphatidyl-1D-myo-inositol+0.0002phosphatidyl-L-serine+0.0004

Other names

4 names

Resolves to: PLIN1

Also called: Lipid droplet-associated proteinPERIPerilipin-1PLIN

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a sphingomyelin

+0.44a triacylglycerol

+0.005fatty acid

→

MAM02392c

Catalysed by PLIN3 or FITM1 or PLIN2 or PLIN1 or PLIN4 or BSCL2 or FITM2

Reaction pageLeft to rightBalance undeterminablecytosol

Human-GEM MAR00031CC BY 4.0Reference data