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Proteins/UNIPROT:Q6IMI6
[Isoform 1]: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds..
[Isoform 2]: Exhibits weak sulphating activity and only toward chloro phenols (pentachlorophenol and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol)..
Function from UniProtKB (Q6IMI6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 2 reference databases · Subject: SULT1C3 · Sources: Rhea, WikiPathways
3 reactions
a phenol+3'-phosphoadenylyl sulfatean aryl sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT1C2 or SULT1B1 or SULT1C4 or SULT1A3 or SULT1A4 or SULT1A1 or SULT1A2 or SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12164CC BY 4.0Reference data
1 name
Resolves to: SULT1C3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22552CC BY 4.0Reference data
lithocholate+3'-phosphoadenylyl sulfatelithocholate 3-sulfate+adenosine 3',5'-bisphosphate+hydron
Catalysed by SULT2A1 or SULT1C3
Reaction pageLeft to rightBalanced
Rhea RHEA:51064CC BY 4.0Reference data