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Proteins/UNIPROT:Q9NRR6
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity)..
Function from UniProtKB (Q9NRR6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
31 statements
31 statements · 6 reference databases · Subject: INPP5E · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
6 reactions
water+MAM02736ca 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+phosphate(3-)
Catalysed by SYNJ2 or OCRL or INPP5E or SYNJ1 or INPP5B
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36cytosol
Human-GEM MAR06552CC BY 4.0Reference data
water+MAM02736na 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+
4 names
Resolves to: INPP5E
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.36nucleus
Human-GEM MAR08817CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data
CHEBI:57836+waterCHEBI:57658+hydrogenphosphate
Catalysed by SYNJ2 or INPPL1 or SYNJ1 or OCRL or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25528CC BY 4.0Reference data
CHEBI:57923+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+hydrogenphosphate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:32955CC BY 4.0Reference data