Proteins/UNIPROT:Q8WZ19

KCTD13

ProteinUNIPROT:Q8WZ19

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). Mediates also the ubiquitination and degradation of GluN1/GRIN1 to regulate excitatory synaptic transmission and seizure susceptibility..

Function from UniProtKB (Q8WZ19), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 4 reference databases · Subject: KCTD13 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ZNF792 covaries with KCTD13ProteinHetionet hetionet:covaries:126375-253980Inferred only
ARMC7 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-79637Inferred only
CUL3 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-8452Inferred only
KAT7 interacts with KCTD13ProteinHetionet hetionet:interacts:11143-253980Inferred only
LNX1 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-84708Inferred only
NUDT18 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-79873Inferred only
PCNA interacts with KCTD13ProteinHetionet hetionet:interacts:253980-5111Inferred only
POLD2 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-5425Inferred only
SPRTN interacts with KCTD13ProteinHetionet hetionet:interacts:253980-83932Inferred only
UBC interacts with KCTD13ProteinHetionet hetionet:interacts:253980-7316Inferred only
VTA1 interacts with KCTD13ProteinHetionet hetionet:interacts:253980-51534Inferred only
ZMYND19 interacts with KCTD13ProteinHetionet hetionet:interacts:116225-253980Inferred only

Show the remaining 10

KCTD13 participates in 16p11 2 proximal deletion syndromePathwayWikiPathways WP4949Inferred only
KCTD13 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
KCTD13 participates in RND2 GTPase cyclePathwayReactome R-HSA-9696270Inferred only
KCTD13 participates in RND3 GTPase cyclePathwayReactome R-HSA-9696264Inferred only
KCTD13 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KCTD13 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
KCTD13 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
KCTD13 regulates negative regulation of Rho protein signal transductionBiological processgene ontology Q8WZ19|GO:0035024Inferred only
KCTD13 regulates positive regulation of DNA replicationBiological processgene ontology Q8WZ19|GO:0045740Inferred only
KCTD13 regulates positive regulation of synaptic transmissionBiological processgene ontology Q8WZ19|GO:0050806Inferred only

Other names

7 names

Resolves to: KCTD13

Also called: BACURD1BTB/POZ domain-containing protein KCTD13hBACURD1PDIP1POLDIP1Polymerase delta-interacting protein 1TNFAIP1-like protein

← Every protein Find it in the graph →