Proteins/UNIPROT:Q7Z6G3

NECAB2

ProteinUNIPROT:Q7Z6G3

May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation..

Function from UniProtKB (Q7Z6G3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

31 statements

31 statements · 2 reference databases · Subject: NECAB2 · Sources: gene ontology, Hetionet

Order

ADORA2A interacts with NECAB2ProteinHetionet hetionet:interacts:135-54550Inferred only
CAPN3 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-825Inferred only
NECAB2 interacts with CCDC121ProteinHetionet hetionet:interacts:54550-79635Inferred only
NECAB2 interacts with CCDC33ProteinHetionet hetionet:interacts:54550-80125Inferred only
CCNK interacts with NECAB2ProteinHetionet hetionet:interacts:54550-8812Inferred only
NECAB2 interacts with CENPOProteinHetionet hetionet:interacts:54550-79172Inferred only
DFFA interacts with NECAB2ProteinHetionet hetionet:interacts:1676-54550Inferred only
NECAB2 interacts with DGCR6LProteinHetionet hetionet:interacts:54550-85359Inferred only
FXR2 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-9513Inferred only
NECAB2 interacts with GTPBP10ProteinHetionet hetionet:interacts:54550-85865Inferred only
ISCU interacts with NECAB2ProteinHetionet hetionet:interacts:23479-54550Inferred only
NECAB2 interacts with KANSL1ProteinHetionet hetionet:interacts:284058-54550Inferred only

Show the remaining 19

NECAB2 interacts with LNX1ProteinHetionet hetionet:interacts:54550-84708Inferred only
MED14 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-9282Inferred only
NEK6 interacts with NECAB2ProteinHetionet hetionet:interacts:10783-54550Inferred only
NECAB2 interacts with NOC4LProteinHetionet hetionet:interacts:54550-79050Inferred only
NECAB2 interacts with NTAQ1ProteinHetionet hetionet:interacts:54550-55093Inferred only
POLR2C interacts with NECAB2ProteinHetionet hetionet:interacts:5432-54550Inferred only
PSMA1 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-5682Inferred only
NECAB2 interacts with RCOR3ProteinHetionet hetionet:interacts:54550-55758Inferred only
RUNX1T1 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-862Inferred only
NECAB2 interacts with TEX11ProteinHetionet hetionet:interacts:54550-56159Inferred only
NECAB2 interacts with USHBP1ProteinHetionet hetionet:interacts:54550-83878Inferred only
USP7 interacts with NECAB2ProteinHetionet hetionet:interacts:54550-7874Inferred only
VTA1 interacts with NECAB2ProteinHetionet hetionet:interacts:51534-54550Inferred only
NECAB2 regulates negative regulation of G protein-coupled receptor internalizationBiological processgene ontology Q7Z6G3|GO:1904021Inferred only
NECAB2 regulates positive regulation of adenosine receptor signaling pathwayBiological processgene ontology Q7Z6G3|GO:0060168Inferred only
NECAB2 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q7Z6G3|GO:0070374Inferred only
NECAB2 regulates positive regulation of glutamate receptor signaling pathwayBiological processgene ontology Q7Z6G3|GO:1900451Inferred only
NECAB2 regulates positive regulation of protein localization to membraneBiological processgene ontology Q7Z6G3|GO:1905477Inferred only
NECAB2 regulates regulation of amyloid precursor protein biosynthetic processBiological processgene ontology Q7Z6G3|GO:0042984Inferred only

Other names

5 names

Resolves to: NECAB2

Also called: EF-hand calcium-binding protein 2EFCBP2Neuronal calcium-binding protein 2Stip-2Synaptotagmin-interacting protein 2

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