Proteins/UNIPROT:Q5VV41

ARHGEF16

ProteinUNIPROT:Q5VV41

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6..

Function from UniProtKB (Q5VV41), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

27 statements

27 statements · 3 reference databases · Subject: ARHGEF16 · Sources: gene ontology, Hetionet, Reactome

Order

ARHGEF16 covaries with ACTRT2ProteinHetionet hetionet:covaries:140625-27237Inferred only
DDIT4L covaries with ARHGEF16ProteinHetionet hetionet:covaries:115265-27237Inferred only
MEGF6 covaries with ARHGEF16ProteinHetionet hetionet:covaries:1953-27237Inferred only
NPAS2 covaries with ARHGEF16ProteinHetionet hetionet:covaries:27237-4862Inferred only
ODAD4 covaries with ARHGEF16ProteinHetionet hetionet:covaries:27237-83538Inferred only
SMARCD3 covaries with ARHGEF16ProteinHetionet hetionet:covaries:27237-6604Inferred only
STAC2 covaries with ARHGEF16ProteinHetionet hetionet:covaries:27237-342667Inferred only
TRIP13 covaries with ARHGEF16ProteinHetionet hetionet:covaries:27237-9319Inferred only
ARHGEF16 interacts with LNX1ProteinHetionet hetionet:interacts:27237-84708Inferred only
YWHAG interacts with ARHGEF16ProteinHetionet hetionet:interacts:27237-7532Inferred only
YWHAZ interacts with ARHGEF16ProteinHetionet hetionet:interacts:27237-7534Inferred only
ARHGEF16 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only

Show the remaining 15

ARHGEF16 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
ARHGEF16 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
ARHGEF16 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
ARHGEF16 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ARHGEF16 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
ARHGEF16 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
ARHGEF16 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGEF16 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only
ARHGEF16 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF16 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ARHGEF16 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF16 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF16 regulates positive regulation of protein localization to plasma membraneBiological processgene ontology Q5VV41|GO:1903078Inferred only
ARHGEF16 regulates regulation of actin cytoskeleton organizationBiological processgene ontology Q5VV41|GO:0032956Inferred only
ARHGEF16 regulates regulation of Cdc42 protein signal transductionBiological processgene ontology Q5VV41|GO:0032489Inferred only

Other names

4 names

Resolves to: ARHGEF16

Also called: Ephexin-4EPHEXIN4NBRRho guanine nucleotide exchange factor 16

← Every protein Find it in the graph →