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Proteins/UNIPROT:O43815

STRN

Protein·UNIPROT:O43815

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Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable)..

Function from UniProtKB (O43815), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

47 statements

47 statements · 4 reference databases · Subject: STRN · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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STRN covaries with CCDC85BProteinHetionet hetionet:covaries:11007-6801Inferred only
HNRNPA0 covaries with STRNProteinHetionet hetionet:covaries:10949-6801Inferred only
SHOX2 covaries with STRNProteinHetionet hetionet:covaries:6474-6801Inferred only
APC interacts with STRNProteinHetionet hetionet:interacts:324-6801Inferred only
STRN interacts with ATF7IPProteinHetionet hetionet:interacts:55729-6801Inferred only
CALM1 interacts with STRNProteinHetionet hetionet:interacts:6801-805Inferred only
CALM1 interacts with STRNProteinHetionet hetionet:interacts:6801-808Inferred only
CALM1 interacts with STRNProteinHetionet hetionet:interacts:6801-801Inferred only
CAV1 interacts with STRNProteinHetionet hetionet:interacts:6801-857Inferred only
ESR1 interacts with STRNProteinHetionet hetionet:interacts:2099-6801Inferred only
STRN interacts with LNX1ProteinHetionet hetionet:interacts:6801-84708Inferred only
STRN interacts with MOB4ProteinHetionet hetionet:interacts:25843-6801Inferred only

Show the remaining 35

STRN interacts with PAXIP1ProteinHetionet hetionet:interacts:22976-6801Inferred only
STRN interacts with PDCD10ProteinHetionet hetionet:interacts:11235-6801Inferred only
PPP2CA interacts with STRNProteinHetionet hetionet:interacts:5515-6801Inferred only
PPP2R1A interacts with STRNProteinHetionet hetionet:interacts:5518-6801Inferred only
PPP2R1B interacts with STRNProteinHetionet hetionet:interacts:5519-6801Inferred only
STRN interacts with SCHIP1ProteinHetionet hetionet:interacts:29970-6801Inferred only
STRN interacts with STK24ProteinHetionet hetionet:interacts:6801-8428Inferred only
STRN interacts with STK25ProteinHetionet hetionet:interacts:10494-6801Inferred only
STRN interacts with STRN3ProteinHetionet hetionet:interacts:29966-6801Inferred only
STRN interacts with TNKS2ProteinHetionet hetionet:interacts:6801-80351Inferred only
STRN interacts with TRAF3IP3ProteinHetionet hetionet:interacts:6801-80342Inferred only
STRN interacts with UBCProteinHetionet hetionet:interacts:6801-7316Inferred only
STRN participates in ALK mutants bind TKIsPathwayReactome R-HSA-9700645Inferred only
STRN participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
STRN participates in DiseasePathwayReactome R-HSA-1643685Inferred only
STRN participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
STRN participates in ESR-mediated signalingPathwayReactome R-HSA-8939211Inferred only
STRN participates in Extra-nuclear estrogen signalingPathwayReactome R-HSA-9009391Inferred only
STRN participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
STRN participates in MET in type 1 papillary renal cell carcinomaPathwayWikiPathways WP4205Inferred only
STRN participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
STRN participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
STRN participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
STRN participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
STRN participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
STRN participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
STRN participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
STRN participates in Signaling by ALK fusions and activated point mutantsPathwayReactome R-HSA-9725370Inferred only
STRN participates in Signaling by ALK in cancerPathwayReactome R-HSA-9700206Inferred only
STRN participates in Signaling by cytosolic PDGFRA and PDGFRB fusion proteinsPathwayReactome R-HSA-9673766Inferred only
STRN participates in Signaling by Nuclear ReceptorsPathwayReactome R-HSA-9006931Inferred only
STRN participates in Signaling by PDGFR in diseasePathwayReactome R-HSA-9671555Inferred only
STRN regulates negative regulation of cell population proliferationBiological processgene ontology O43815|GO:0008285Inferred only
STRN regulates regulation of hippo signalingBiological processgene ontology O43815|GO:0035330Inferred only
STRN regulates regulation of signal transductionBiological processgene ontology O43815|GO:0009966Inferred only

Other names

1 name

Resolves to: STRN

Also called: Striatin

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