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Proteins/UNIPROT:P25100

ADRA1D

Protein·UNIPROT:P25100

Open in the graph

Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine..

Function from UniProtKB (P25100), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

28 statements

28 statements · 4 reference databases · Subject: ADRA1D · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ADRA1D covaries with TPM3ProteinHetionet hetionet:covaries:146-7170Inferred only
ADRA1D interacts with ADRA1AProteinHetionet hetionet:interacts:146-148Inferred only
ADRA1D interacts with FLNCProteinHetionet hetionet:interacts:146-2318Inferred only
ADRA1D interacts with LNX1ProteinHetionet hetionet:interacts:146-84708Inferred only
ADRA1D interacts with NOS1ProteinHetionet hetionet:interacts:146-4842Inferred only
ADRA1D interacts with SNTA1ProteinHetionet hetionet:interacts:146-6640Inferred only
ADRA1D interacts with SNTB1ProteinHetionet hetionet:interacts:146-6641Inferred only
ADRA1D interacts with SNTG1ProteinHetionet hetionet:interacts:146-54212Inferred only
ADRA1D participates in AdrenoceptorsPathwayReactome R-HSA-390696Inferred only
ADRA1D participates in Amine ligand-binding receptorsPathwayReactome R-HSA-375280Inferred only
ADRA1D participates in Caffeine in blood vesselsPathwayWikiPathways WP5601Inferred only
ADRA1D participates in Caffeine in neuronsPathwayWikiPathways WP5602Inferred only

Show the remaining 16

ADRA1D participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
ADRA1D participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
ADRA1D participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
ADRA1D participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
ADRA1D participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ADRA1D participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
ADRA1D participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
ADRA1D participates in GPCRs otherPathwayWikiPathways WP117Inferred only
ADRA1D participates in Major receptors targeted by epinephrine and norepinephrinePathwayWikiPathways WP4589Inferred only
ADRA1D participates in Monoamine GPCRsPathwayWikiPathways WP58Inferred only
ADRA1D participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ADRA1D participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ADRA1D regulates positive regulation of cell population proliferationBiological processgene ontology P25100|GO:0008284Inferred only
ADRA1D regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P25100|GO:0007204Inferred only
ADRA1D regulates positive regulation of MAPK cascadeBiological processgene ontology P25100|GO:0043410Inferred only
ADRA1D regulates positive regulation of vasoconstrictionBiological processgene ontology P25100|GO:0045907Inferred only

Other names

5 names

Resolves to: ADRA1D

Also called: ADRA1AAlpha-1A adrenergic receptorAlpha-1D adrenoceptorAlpha-1D adrenoreceptorAlpha-adrenergic receptor 1a

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