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Proteins/UNIPROT:P43119

PTGIR

Protein·UNIPROT:P43119

Open in the graph

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Function from UniProtKB (P43119), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

26 statements

26 statements · 4 reference databases · Subject: PTGIR · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PTGIR interacts with ADCY10ProteinHetionet hetionet:interacts:55811-5739Inferred only
GNA11 interacts with PTGIRProteinHetionet hetionet:interacts:2767-5739Inferred only
GNAQ interacts with PTGIRProteinHetionet hetionet:interacts:2776-5739Inferred only
GNAS interacts with PTGIRProteinHetionet hetionet:interacts:2778-5739Inferred only
PTGIR interacts with LNX1ProteinHetionet hetionet:interacts:5739-84708Inferred only
PRKCA interacts with PTGIRProteinHetionet hetionet:interacts:5578-5739Inferred only
PTGIR interacts with UBCProteinHetionet hetionet:interacts:5739-7316Inferred only
PTGIR participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
PTGIR participates in Eicosanoid ligand-binding receptorsPathwayReactome R-HSA-391903Inferred only
PTGIR participates in Eicosanoid metabolism via cyclooxygenases COX PathwayWikiPathways WP4719Inferred only
PTGIR participates in Endothelin pathwaysPathwayWikiPathways WP2197Inferred only
PTGIR participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only

Show the remaining 14

PTGIR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
PTGIR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
PTGIR participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
PTGIR participates in HemostasisPathwayReactome R-HSA-109582Inferred only
PTGIR participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only
PTGIR participates in Prostacyclin signalling through prostacyclin receptorPathwayReactome R-HSA-392851Inferred only
PTGIR participates in Prostaglandin synthesis and regulationPathwayWikiPathways WP98Inferred only
PTGIR participates in Prostanoid ligand receptorsPathwayReactome R-HSA-391908Inferred only
PTGIR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTGIR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PTGIR participates in Small ligand GPCRsPathwayWikiPathways WP247Inferred only
PTGIR regulates negative regulation of platelet-derived growth factor receptor signaling pathwayBiological processgene ontology P43119|GO:0010642Inferred only
PTGIR regulates negative regulation of smooth muscle cell proliferationBiological processgene ontology P43119|GO:0048662Inferred only
PTGIR regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P43119|GO:0007204Inferred only

Other names

5 names

Resolves to: PTGIR

Also called: PGI receptorPGI2 receptorPRIPRProstaglandin I2 receptorProstanoid IP receptor

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