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Proteins/UNIPROT:O75352

MPDU1

Protein·UNIPROT:O75352

Open in the graph

Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors..

Function from UniProtKB (O75352), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

MPDU1-congenital disorder of glycosylation has a germline basis in MPDU1DiseaseGenCC HGNC:7207|MONDO:0012211Inferred only

Statements

23 statements

23 statements · 3 reference databases · Subject: MPDU1 · Sources: Hetionet, Reactome, WikiPathways

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SHBG interacts with MPDU1ProteinHetionet hetionet:interacts:6462-9526Inferred only
UBC interacts with MPDU1ProteinHetionet hetionet:interacts:7316-9526Inferred only
MPDU1 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
MPDU1 participates in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinPathwayReactome R-HSA-446193Inferred only
MPDU1 participates in Defective MPDU1 causes CDG-1fPathwayReactome R-HSA-4687000Inferred only
MPDU1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
MPDU1 participates in Diseases associated with N-glycosylation of proteinsPathwayReactome R-HSA-3781860Inferred only
MPDU1 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
MPDU1 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
MPDU1 participates in Glycosylation and related congenital defectsPathwayWikiPathways WP4521Inferred only
MPDU1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MPDU1 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only

Show the remaining 11

MPDU1 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
MPDU1 participates in N glycan biosynthesisPathwayWikiPathways WP5153Inferred only
MPDU1 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
EPHA2 increases the expression of MPDU1ProteinHetionet hetionet:regulates:1969-9526Inferred only
ERBB2 decreases the expression of MPDU1ProteinHetionet hetionet:regulates:2064-9526Inferred only
GLI1 decreases the expression of MPDU1ProteinHetionet hetionet:regulates:2735-9526Inferred only
HEBP1 increases the expression of MPDU1ProteinHetionet hetionet:regulates:50865-9526Inferred only
NELFE decreases the expression of MPDU1ProteinHetionet hetionet:regulates:7936-9526Inferred only
SPAG7 decreases the expression of MPDU1ProteinHetionet hetionet:regulates:9552-9526Inferred only
TMEM109 decreases the expression of MPDU1ProteinHetionet hetionet:regulates:79073-9526Inferred only
UGDH decreases the expression of MPDU1ProteinHetionet hetionet:regulates:7358-9526Inferred only

Other names

2 names

Resolves to: MPDU1

Also called: SL15Suppressor of Lec15 and Lec35 glycosylation mutation homolog

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