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Proteins/UNIPROT:P57727

TMPRSS3

Protein·UNIPROT:P57727

Open in the graph

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro)..

Function from UniProtKB (P57727), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

autosomal recessive nonsyndromic hearing loss 8 has a germline basis in TMPRSS3DiseaseGenCC HGNC:11877|MONDO:0010987Inferred only
hearing loss, autosomal recessive has a germline basis in TMPRSS3DiseaseGenCC HGNC:11877|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in TMPRSS3DiseaseGenCC HGNC:11877|MONDO:0019497Inferred only

Statements

3 statements

3 statements · 1 reference database · Subject: TMPRSS3 · Sources: Hetionet

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EEF1A1 interacts with TMPRSS3ProteinHetionet hetionet:interacts:1915-64699Inferred only
RXRA interacts with TMPRSS3ProteinHetionet hetionet:interacts:6256-64699Inferred only
TMED7 interacts with TMPRSS3ProteinHetionet hetionet:interacts:51014-64699Inferred only

Other names

4 names

Resolves to: TMPRSS3

Also called: ECHOS1Serine protease TADG-12TADG12Tumor-associated differentially-expressed gene 12 protein

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