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Proteins/UNIPROT:Q9HCU9
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma..
Function from UniProtKB (Q9HCU9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
57 statements
57 statements · 3 reference databases · Subject: BRMS1 · Sources: gene ontology, Hetionet, Reactome
1 name
Resolves to: BRMS1