Proteins/UNIPROT:P09466

PAEP

ProteinUNIPROT:P09466

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa..

Function from UniProtKB (P09466), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 2 reference databases · Subject: PAEP · Sources: gene ontology, Hetionet

Order

A2M interacts with PAEPProteinHetionet hetionet:interacts:2-5047Inferred only
APP interacts with PAEPProteinHetionet hetionet:interacts:351-5047Inferred only
PAEP interacts with COPS6ProteinHetionet hetionet:interacts:10980-5047Inferred only
EEF1A1 interacts with PAEPProteinHetionet hetionet:interacts:1915-5047Inferred only
PAEP interacts with IGSF21ProteinHetionet hetionet:interacts:5047-84966Inferred only
PAEP interacts with LRIF1ProteinHetionet hetionet:interacts:5047-55791Inferred only
PAEP interacts with PTPRCProteinHetionet hetionet:interacts:5047-5788Inferred only
PAEP interacts with RIF1ProteinHetionet hetionet:interacts:5047-55183Inferred only
SMAD3 interacts with PAEPProteinHetionet hetionet:interacts:4088-5047Inferred only
PAEP interacts with UBE2E1ProteinHetionet hetionet:interacts:5047-7324Inferred only
XRCC6 interacts with PAEPProteinHetionet hetionet:interacts:2547-5047Inferred only
PAEP regulates negative regulation of sperm capacitationBiological processgene ontology P09466|GO:1902491Inferred only

Show the remaining 2

PAEP regulates positive regulation of granulocyte macrophage colony-stimulating factor productionBiological processgene ontology P09466|GO:0032725Inferred only
PAEP regulates regulation of binding of sperm to zona pellucidaBiological processgene ontology P09466|GO:2000359Inferred only

Other names

10 names

Resolves to: PAEP

Also called: GDPAEGPEGPlacental protein 14PP14Pregnancy-associated endometrial alpha-2 globulinProgestagen-associated endometrial proteinProgesterone-associated endometrial proteinZIF-1Zona-binding inhibitory factor-1

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