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Proteins/UNIPROT:P29074
Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton..
Function from UniProtKB (P29074), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
40 statements
40 statements · 2 reference databases · Subject: PTPN4 · Sources: Hetionet, Reactome
1 reaction
3 names
Resolves to: PTPN4