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Proteins/UNIPROT:Q8IZL2

MAML2

Protein·UNIPROT:Q8IZL2

Open in the graph

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3..

Function from UniProtKB (Q8IZL2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

55 statements

55 statements · 4 reference databases · Subject: MAML2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

ACKR4 covaries with MAML2ProteinHetionet hetionet:covaries:51554-84441Inferred only
MAML2 covaries with AMOTL1ProteinHetionet hetionet:covaries:154810-84441Inferred only
ANKRD34C covaries with MAML2ProteinHetionet hetionet:covaries:390616-84441Inferred only
ARHGAP20 covaries with MAML2ProteinHetionet hetionet:covaries:57569-84441Inferred only
CLEC7A covaries with MAML2ProteinHetionet hetionet:covaries:64581-84441Inferred only
MAML2 covaries with ENDOD1ProteinHetionet hetionet:covaries:23052-84441Inferred only
FBXL22 covaries with MAML2ProteinHetionet hetionet:covaries:283807-84441Inferred only
FUT2 covaries with MAML2ProteinHetionet hetionet:covaries:2524-84441Inferred only
ITK covaries with MAML2ProteinHetionet hetionet:covaries:3702-84441Inferred only
MED21 covaries with MAML2ProteinHetionet hetionet:covaries:84441-9412Inferred only
PTHLH covaries with MAML2ProteinHetionet hetionet:covaries:5744-84441Inferred only
RPL35A covaries with MAML2ProteinHetionet hetionet:covaries:6165-84441Inferred only

Show the remaining 43

SCRT2 covaries with MAML2ProteinHetionet hetionet:covaries:84441-85508Inferred only
ZNF514 covaries with MAML2ProteinHetionet hetionet:covaries:84441-84874Inferred only
DIABLO interacts with MAML2ProteinHetionet hetionet:interacts:56616-84441Inferred only
NOTCH1 interacts with MAML2ProteinHetionet hetionet:interacts:4851-84441Inferred only
NOTCH2 interacts with MAML2ProteinHetionet hetionet:interacts:4853-84441Inferred only
NOTCH3 interacts with MAML2ProteinHetionet hetionet:interacts:4854-84441Inferred only
NOTCH4 interacts with MAML2ProteinHetionet hetionet:interacts:4855-84441Inferred only
MAML2 participates in Canonical and non canonical Notch signalingPathwayWikiPathways WP3845Inferred only
MAML2 participates in Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsPathwayReactome R-HSA-2894862Inferred only
MAML2 participates in Constitutive Signaling by NOTCH1 PEST Domain MutantsPathwayReactome R-HSA-2644606Inferred only
MAML2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MAML2 participates in Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)PathwayReactome R-HSA-9976102Inferred only
MAML2 participates in Differentiation of T cellsPathwayReactome R-HSA-9945266Inferred only
MAML2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
MAML2 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
MAML2 participates in Formation of paraxial mesodermPathwayReactome R-HSA-9793380Inferred only
MAML2 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
MAML2 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
MAML2 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
MAML2 participates in Notch signalingPathwayWikiPathways WP61Inferred only
MAML2 participates in Notch-HLH transcription pathwayPathwayReactome R-HSA-350054Inferred only
MAML2 participates in NOTCH1 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-2122947Inferred only
MAML2 participates in NOTCH2 intracellular domain regulates transcriptionPathwayReactome R-HSA-2197563Inferred only
MAML2 participates in NOTCH3 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-9013508Inferred only
MAML2 participates in NOTCH4 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-9013695Inferred only
MAML2 participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
MAML2 participates in Pre-NOTCH Transcription and TranslationPathwayReactome R-HSA-1912408Inferred only
MAML2 participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
MAML2 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsPathwayReactome R-HSA-210744Inferred only
MAML2 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
MAML2 participates in RUNX3 regulates NOTCH signalingPathwayReactome R-HSA-8941856Inferred only
MAML2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MAML2 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
MAML2 participates in Signaling by NOTCH1PathwayReactome R-HSA-1980143Inferred only
MAML2 participates in Signaling by NOTCH1 HD+PEST Domain Mutants in CancerPathwayReactome R-HSA-2894858Inferred only
MAML2 participates in Signaling by NOTCH1 in CancerPathwayReactome R-HSA-2644603Inferred only
MAML2 participates in Signaling by NOTCH1 PEST Domain Mutants in CancerPathwayReactome R-HSA-2644602Inferred only
MAML2 participates in Signaling by NOTCH2PathwayReactome R-HSA-1980145Inferred only
MAML2 participates in Signaling by NOTCH3PathwayReactome R-HSA-9012852Inferred only
MAML2 participates in Signaling by NOTCH4PathwayReactome R-HSA-9013694Inferred only
MAML2 participates in Transcriptional regulation by RUNX3PathwayReactome R-HSA-8878159Inferred only
MAML2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q8IZL2|GO:0045944Inferred only
MAML2 regulates positive regulation of transcription of Notch receptor targetBiological processgene ontology Q8IZL2|GO:0007221Inferred only

Other names

3 names

Resolves to: MAML2

Also called: KIAA1819Mam-2Mastermind-like protein 2

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