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Proteins/UNIPROT:O95750

FGF19

Protein·UNIPROT:O95750

Open in the graph

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4..

Function from UniProtKB (O95750), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

53 statements

53 statements · 4 reference databases · Subject: FGF19 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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FGFR1 interacts with FGF19ProteinHetionet hetionet:interacts:2260-9965Inferred only
FGFR4 interacts with FGF19ProteinHetionet hetionet:interacts:2264-9965Inferred only
FGF19 participates in 5q35 copy number variationPathwayWikiPathways WP5380Inferred only
FGF19 participates in betaKlotho-mediated ligand bindingPathwayReactome R-HSA-1307965Inferred only
FGF19 participates in Bile acid synthesis and enterohepatic circulation PathwayWikiPathways WP4389Inferred only
FGF19 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
FGF19 participates in Constitutive Signaling by Aberrant PI3K in CancerPathwayReactome R-HSA-2219530Inferred only
FGF19 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
FGF19 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
FGF19 participates in Downstream signaling of activated FGFR4PathwayReactome R-HSA-5654716Inferred only
FGF19 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only
FGF19 participates in Farnesoid X receptor pathwayPathwayWikiPathways WP2879Inferred only

Show the remaining 41

FGF19 participates in FGFR4 ligand binding and activationPathwayReactome R-HSA-190322Inferred only
FGF19 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
FGF19 participates in FRS-mediated FGFR4 signalingPathwayReactome R-HSA-5654712Inferred only
FGF19 participates in IGF1R signaling cascadePathwayReactome R-HSA-2428924Inferred only
FGF19 participates in Insulin receptor signalling cascadePathwayReactome R-HSA-74751Inferred only
FGF19 participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
FGF19 participates in IRS-mediated signallingPathwayReactome R-HSA-112399Inferred only
FGF19 participates in IRS-related events triggered by IGF1RPathwayReactome R-HSA-2428928Inferred only
FGF19 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
FGF19 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
FGF19 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
FGF19 participates in Negative regulation of FGFR4 signalingPathwayReactome R-HSA-5654733Inferred only
FGF19 participates in Negative regulation of the PI3K/AKT networkPathwayReactome R-HSA-199418Inferred only
FGF19 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
FGF19 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
FGF19 participates in Phospholipase C-mediated cascade; FGFR4PathwayReactome R-HSA-5654228Inferred only
FGF19 participates in PI-3K cascade:FGFR4PathwayReactome R-HSA-5654720Inferred only
FGF19 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
FGF19 participates in PI3K CascadePathwayReactome R-HSA-109704Inferred only
FGF19 participates in PI3K/AKT Signaling in CancerPathwayReactome R-HSA-2219528Inferred only
FGF19 participates in PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPathwayReactome R-HSA-6811558Inferred only
FGF19 participates in PIP3 activates AKT signalingPathwayReactome R-HSA-1257604Inferred only
FGF19 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
FGF19 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
FGF19 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
FGF19 participates in SHC-mediated cascade:FGFR4PathwayReactome R-HSA-5654719Inferred only
FGF19 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGF19 participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
FGF19 participates in Signaling by FGFR4PathwayReactome R-HSA-5654743Inferred only
FGF19 participates in Signaling by Insulin receptorPathwayReactome R-HSA-74752Inferred only
FGF19 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
FGF19 participates in Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)PathwayReactome R-HSA-2404192Inferred only
FGF19 regulates negative regulation of bile acid biosynthetic processBiological processgene ontology O95750|GO:0070858Inferred only
FGF19 regulates negative regulation of gene expressionBiological processgene ontology O95750|GO:0010629Inferred only
FGF19 regulates positive regulation of cell population proliferationBiological processgene ontology O95750|GO:0008284Inferred only
FGF19 regulates positive regulation of D-glucose import across plasma membraneBiological processgene ontology O95750|GO:0046326Inferred only
FGF19 regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology O95750|GO:0070374Inferred only
FGF19 regulates positive regulation of JNK cascadeBiological processgene ontology O95750|GO:0046330Inferred only
FGF19 regulates positive regulation of MAPK cascadeBiological processgene ontology O95750|GO:0043410Inferred only
FGF19 regulates positive regulation of protein phosphorylationBiological processgene ontology O95750|GO:0001934Inferred only
FGF19 regulates regulation of cell migrationBiological processgene ontology O95750|GO:0030334Inferred only

Other names

2 names

Resolves to: FGF19

Also called: FGF-19Fibroblast growth factor 19

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