Proteins/UNIPROT:Q9C030

TRIM6

ProteinUNIPROT:Q9C030

E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Also ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response..

(Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity..

Function from UniProtKB (Q9C030), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 3 reference databases · Subject: TRIM6 · Sources: gene ontology, Hetionet, Reactome

Order

MYC interacts with TRIM6ProteinHetionet hetionet:interacts:117854-4609Inferred only
TRIM5 interacts with TRIM6ProteinHetionet hetionet:interacts:117854-85363Inferred only
TRIM6 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
TRIM6 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TRIM6 participates in Interferon gamma signalingPathwayReactome R-HSA-877300Inferred only
TRIM6 participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
TRIM6 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9C030|GO:0045892Inferred only
TRIM6 regulates negative regulation of gene expressionBiological processgene ontology Q9C030|GO:0010629Inferred only
TRIM6 regulates negative regulation of stem cell differentiationBiological processgene ontology Q9C030|GO:2000737Inferred only
TRIM6 regulates negative regulation of viral genome replicationBiological processgene ontology Q9C030|GO:0045071Inferred only
TRIM6 regulates positive regulation of cytokine production involved in immune responseBiological processgene ontology Q9C030|GO:0002720Inferred only
TRIM6 regulates positive regulation of defense response to virus by hostBiological processgene ontology Q9C030|GO:0002230Inferred only

Show the remaining 5

TRIM6 regulates positive regulation of peptidyl-serine phosphorylationBiological processgene ontology Q9C030|GO:0033138Inferred only
TRIM6 regulates positive regulation of peptidyl-threonine phosphorylationBiological processgene ontology Q9C030|GO:0010800Inferred only
TRIM6 regulates positive regulation of transcription regulatory region DNA bindingBiological processgene ontology Q9C030|GO:2000679Inferred only
TRIM6 regulates positive regulation of type I interferon-mediated signaling pathwayBiological processgene ontology Q9C030|GO:0060340Inferred only
TRIM6 regulates regulation of gene expressionBiological processgene ontology Q9C030|GO:0010468Inferred only

Other names

3 names

Resolves to: TRIM6

Also called: RING finger protein 89RING-type E3 ubiquitin transferase TRIM6RNF89

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