Proteins/UNIPROT:Q9BWX5

GATA5

ProteinUNIPROT:Q9BWX5

Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer..

Function from UniProtKB (Q9BWX5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

congenital heart defects, multiple types, 5 has a germline basis in GATA5DiseaseGenCC HGNC:15802|MONDO:0060663Inferred only
familial atrial fibrillation has a germline basis in GATA5DiseaseGenCC HGNC:15802|MONDO:0018054Inferred only
familial bicuspid aortic valve has a germline basis in GATA5DiseaseGenCC HGNC:15802|MONDO:0007194Inferred only
tetralogy of fallot has a germline basis in GATA5DiseaseGenCC HGNC:15802|MONDO:0008542Inferred only

Statements

22 statements

22 statements · 3 reference databases · Subject: GATA5 · Sources: gene ontology, Hetionet, Reactome

Order

ADAMTSL2 covaries with GATA5ProteinHetionet hetionet:covaries:140628-9719Inferred only
BIRC7 covaries with GATA5ProteinHetionet hetionet:covaries:140628-79444Inferred only
GPR22 covaries with GATA5ProteinHetionet hetionet:covaries:140628-2845Inferred only
GATA5 covaries with LAMA5ProteinHetionet hetionet:covaries:140628-3911Inferred only
MEX3D covaries with GATA5ProteinHetionet hetionet:covaries:140628-399664Inferred only
GATA5 covaries with PAX7ProteinHetionet hetionet:covaries:140628-5081Inferred only
SLC29A4 covaries with GATA5ProteinHetionet hetionet:covaries:140628-222962Inferred only
SLU7 covaries with GATA5ProteinHetionet hetionet:covaries:10569-140628Inferred only
GATA5 covaries with TNFAIP8L1ProteinHetionet hetionet:covaries:126282-140628Inferred only
GATA5 covaries with ZC3H18ProteinHetionet hetionet:covaries:124245-140628Inferred only
EP300 interacts with GATA5ProteinHetionet hetionet:interacts:140628-2033Inferred only
HNF1A interacts with GATA5ProteinHetionet hetionet:interacts:140628-6927Inferred only

Show the remaining 10

KLF2 interacts with GATA5ProteinHetionet hetionet:interacts:10365-140628Inferred only
GATA5 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
GATA5 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
GATA5 regulates negative regulation of cardiac muscle hypertrophyBiological processgene ontology Q9BWX5|GO:0010614Inferred only
GATA5 regulates negative regulation of gene expressionBiological processgene ontology Q9BWX5|GO:0010629Inferred only
GATA5 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9BWX5|GO:0000122Inferred only
GATA5 regulates positive regulation of cardiac endothelial to mesenchymal transitionBiological processgene ontology Q9BWX5|GO:0062000Inferred only
GATA5 regulates positive regulation of gene expressionBiological processgene ontology Q9BWX5|GO:0010628Inferred only
GATA5 regulates positive regulation of Notch signaling pathwayBiological processgene ontology Q9BWX5|GO:0045747Inferred only
GATA5 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9BWX5|GO:0045944Inferred only

Other names

3 names

Resolves to: GATA5

Also called: GATA-5GATA-binding factor 5Transcription factor GATA-5

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