Proteins/UNIPROT:Q5TCY1

TTBK1

ProteinUNIPROT:Q5TCY1

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU..

Curated compounds routed: 0

What the reference databases state

17 statements

17 statements · 4 reference databases · Subject: TTBK1 · Sources: gene ontology, Hetionet, UniProt, WikiPathways

Order

CDK5R1 interacts with TTBK1ProteinHetionet hetionet:interacts:84630-8851Inferred only
CSN1S1 interacts with TTBK1ProteinHetionet hetionet:interacts:1446-84630Inferred only
HEATR1 interacts with TTBK1ProteinHetionet hetionet:interacts:55127-84630Inferred only
MAP2 interacts with TTBK1ProteinHetionet hetionet:interacts:4133-84630Inferred only
TTBK1 interacts with TUBBProteinHetionet hetionet:interacts:203068-84630Inferred only
TTBK1 participates in Ras signalingPathwayWikiPathways WP4223Inferred only
TTBK1 regulates negative regulation of gene expressionBiological processgene ontology Q5TCY1|GO:0010629Inferred only
TTBK1 regulates positive regulation of astrocyte activationBiological processgene ontology Q5TCY1|GO:0061890Inferred only
TTBK1 regulates positive regulation of gene expressionBiological processgene ontology Q5TCY1|GO:0010628Inferred only
TTBK1 regulates positive regulation of microglial cell activationBiological processgene ontology Q5TCY1|GO:1903980Inferred only
TTBK1 regulates positive regulation of protein polymerizationBiological processgene ontology Q5TCY1|GO:0032273Inferred only
TTBK1 decreases the expression of DNM1LProteinHetionet hetionet:regulates:84630-10059Inferred only

Show the remaining 5

TTBK1 decreases the expression of METRNProteinHetionet hetionet:regulates:84630-79006Inferred only
TTBK1 decreases the expression of STEAP1ProteinHetionet hetionet:regulates:84630-26872Inferred only
TTBK1 decreases the expression of TMEM50AProteinHetionet hetionet:regulates:84630-23585Inferred only
TTBK1 requires the cofactor magnesium(2+)CompoundUniProt Q5TCY1Inferred only
TTBK1 requires the cofactor Mn(2+)CompoundUniProt Q5TCY1Inferred only

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

3 names

Resolves to: TTBK1