Proteins/UNIPROT:O75339

CILP

ProteinUNIPROT:O75339

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage..

Function from UniProtKB (O75339), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: CILP · Sources: gene ontology, Hetionet, Reactome

Order

COX6A2 covaries with CILPProteinHetionet hetionet:covaries:1339-8483Inferred only
CILP covaries with CRIP1ProteinHetionet hetionet:covaries:1396-8483Inferred only
DDIT4L covaries with CILPProteinHetionet hetionet:covaries:115265-8483Inferred only
EMILIN2 covaries with CILPProteinHetionet hetionet:covaries:84034-8483Inferred only
FAM171A2 covaries with CILPProteinHetionet hetionet:covaries:284069-8483Inferred only
CILP covaries with GPRC5AProteinHetionet hetionet:covaries:8483-9052Inferred only
CILP covaries with JRKLProteinHetionet hetionet:covaries:8483-8690Inferred only
CILP covaries with OR5M8ProteinHetionet hetionet:covaries:219484-8483Inferred only
OR8K5 covaries with CILPProteinHetionet hetionet:covaries:219453-8483Inferred only
PPL covaries with CILPProteinHetionet hetionet:covaries:5493-8483Inferred only
TIGD7 covaries with CILPProteinHetionet hetionet:covaries:8483-91151Inferred only
XKR6 covaries with CILPProteinHetionet hetionet:covaries:286046-8483Inferred only

Show the remaining 7

CILP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CILP participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
CILP participates in Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)PathwayReactome R-HSA-2404192Inferred only
CILP regulates negative regulation of gene expressionBiological processgene ontology O75339|GO:0010629Inferred only
CILP regulates negative regulation of insulin-like growth factor receptor signaling pathwayBiological processgene ontology O75339|GO:0043569Inferred only
CILP regulates negative regulation of SMAD protein signal transductionBiological processgene ontology O75339|GO:0060392Inferred only
CILP regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology O75339|GO:0030512Inferred only

Other names

3 names

Resolves to: CILP

Also called: [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2]Cartilage intermediate-layer proteinCILP-1

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