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Proteins/UNIPROT:P26012

ITGB8

Protein·UNIPROT:P26012

Open in the graph

Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity)..

Function from UniProtKB (P26012), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

22 statements

22 statements · 4 reference databases · Subject: ITGB8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ITGAV interacts with ITGB8ProteinHetionet hetionet:interacts:3685-3696Inferred only
ITGB8 interacts with TGFB1ProteinHetionet hetionet:interacts:3696-7040Inferred only
ITGB8 interacts with UBCProteinHetionet hetionet:interacts:3696-7316Inferred only
ITGB8 interacts with VTNProteinHetionet hetionet:interacts:3696-7448Inferred only
ITGB8 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
ITGB8 participates in Elastic fibre formationPathwayReactome R-HSA-1566948Inferred only
ITGB8 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ITGB8 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
ITGB8 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
ITGB8 participates in Hippo Merlin signaling dysregulationPathwayWikiPathways WP4541Inferred only
ITGB8 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only
ITGB8 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only

Show the remaining 10

ITGB8 participates in Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanismsPathwayWikiPathways WP4534Inferred only
ITGB8 participates in Molecules associated with elastic fibresPathwayReactome R-HSA-2129379Inferred only
ITGB8 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
ITGB8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ITGB8 participates in Signaling by TGF-beta Receptor ComplexPathwayReactome R-HSA-170834Inferred only
ITGB8 participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
ITGB8 participates in TGF-beta receptor signaling activates SMADsPathwayReactome R-HSA-2173789Inferred only
ITGB8 regulates negative regulation of gene expressionBiological processgene ontology P26012|GO:0010629Inferred only
ITGB8 regulates positive regulation of angiogenesisBiological processgene ontology P26012|GO:0045766Inferred only
ITGB8 regulates positive regulation of gene expressionBiological processgene ontology P26012|GO:0010628Inferred only

Other names

1 name

Resolves to: ITGB8

Also called: Integrin beta-8

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