(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA

Two steps

• hexacosanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 10 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• heptadecanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• nonadecanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 3 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• 1-O-alkyl-3-acylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by MOGAT2, AWAT2cytosol

• dodecanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Activation of dodecanedioic acid

  Catalysed by BAAT, ACOT6cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Production of Sebacoylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Production of Suberylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by BAAT, ACOT6cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by BAAT, ACOT6, CRAT, CROTcytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by BAAT, ACOT6, ACAA1, HSD17B4 and 2 morecytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Production of Hexadecanedioylcarnitine

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• pristanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. fatty-acid-CoA ligase

  Catalysed by BAAT, ACOT6, SLC27A2cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by MOGAT1cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT2, LPCAT1cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4cytosol

• undecanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by BAAT, ACOT6, ACSM4, ACSM1 and 4 morecytosolOne of 3 routes

• (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoAReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + O2 = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H2O2

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1peroxisome

• 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome

• (5Z)-tetradecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• (3E)-decenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by BAAT, ACOT6, ACADM, ECHS1 and 2 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by BAAT, ACOT6, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by GLYATL1B, GLYATL1cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol