CHEBI:63544

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

702 compounds within 3 steps: 6 in 1, 148 in 2, 548 in 3

Three steps

(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosolOne of 2 routes
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosolOne of 2 routes
hexadecanoateReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
Catalysed by LPCAT1, PNPLA8cytosol
tricosanoateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by BAAT, ACOT6cytosol, extracellular spaceOne of 13 routes
(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. Arachidonate: oxygen 11-oxidoreductase
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosolOne of 2 routes
prostaglandin G2Reach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. Arachidonate:oxygen oxidoreductase
Catalysed by ACADM, ACADS, ACOT7, BAAT and 5 moremitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by BAAT, ACOT6, NAGS, MOCOScytosol, mitochondrial matrix
cholesteryl octadecanoateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol, endoplasmic reticulumOne of 6 routes
N-octadecanoylhexadecasphinganineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecasphinganine + octadecanoyl-CoA = N-octadecanoylhexadecasphinganine + CoA + H(+)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate
Catalysed by AGPAT4, LPIN1cytosol
glycodeoxycholateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
3. deoxycholoyl-CoA to glycodeoxycholate conversion
Catalysed by BAAT, ACOT6, SLC27A2, SLC27A5cytosolOne of 3 routes
14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoateReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate
Catalysed by BAAT, ACOT6, ALOX12Bcytosol
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
sphinga-4E,14Z-dienineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by BAAT, ACOT6, ASAH1, ACER2 and 3 morecytosol, Golgi apparatus
1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. unspecific monooxygenase (arachidonate)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 30 moremitochondrial matrix, cytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. unspecific monooxygenase (arachidonate)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 29 moremitochondrial matrix, cytosolOne of 3 routes
cholesteryl (9Z)-hexadecenoateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 8 morecytosol, endoplasmic reticulumOne of 5 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
a monoacyl-sn-glycero-3-phosphocholineReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
Catalysed by LPGAT1, PNLIPRP2cytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
2-(acylamino)ethyl fatty acidReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 2 routes
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 8 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
O-tetradecanoyl-(R)-carnitineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
O-octadecanoyl-(R)-carnitineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol
O-eicosanoyl-(R)-carnitineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol
O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 3 morecytosol, peroxisomeOne of 7 routes
1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
Catalysed by LPGAT1, PLD1cytosol
(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + O2 = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H2O2
3. (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)
Catalysed by ACOX1, DECR2cytosol
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. fatty acyl-CoA desaturase (N-C22:4CoA -> N-C22:5CoA)
2. Beta Oxidation of Long Chain Fatty Acid
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 2 moreperoxisome, endoplasmic reticulumOne of 6 routes
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
Catalysed by AGPAT4, CDS2, CDS1cytosol
N-tetradecanoylglycineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes
N-eicosanoylglycinateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 2 routes
N-docosanoylglycineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 2 routes
N-hexacosanoylglycineReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 2 routes
(2E,5Z)-tetradecadienoyl-CoAReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)
3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 10 morecytosol, mitochondrial matrixOne of 4 routes
(2E,7Z)-hexadecadienoyl-CoAReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)
Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 10 morecytosol, mitochondrial matrixOne of 4 routes
cholesteryl (11Z)-octadecenoateReach from here →
1. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 2 morecytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol
17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O
Catalysed by BAAT, ACOT6, PTGS2cytosol
13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoateReach from here →
1. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA reduction
2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O
Catalysed by BAAT, ACOT6, PTGS2cytosol
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. Beta Oxidation of Long Chain Fatty Acid
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by ACADM, ACADS, ACOT7, BAAT and 4 moremitochondrial matrix, cytosol