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Reach

cholate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

414 compounds within 3 steps: 6 in 1, 95 in 2, 313 in 3

Does it reach a compound?

Two steps

taurochenodeoxycholateReach from here →
1. solute carrier organic anion transporter (cholate)
2. solute carrier organic anion transporter (GSH)
Catalysed by SLCO1A2, SLCO1B3, SLC7A9extracellular space, cytosolOne of 5 routes

Three steps

(S)-carnitineReach from here →
Catalysed by SLC27A2, SLC27A5, BAAT, CPT1A and 2 moreendoplasmic reticulum, peroxisome, cytosolOne of 246 routes
(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

Page 3 of 9

Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 8 moreextracellular space, cytosol

AReach from here →

solute carrier organic anion transporter (cholate)
transport of GSH and thyroxine (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3extracellular space, cytosolOne of 11 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 6 moreextracellular space, cytosol

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 6 moreextracellular space, cytosol

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP2C8, CYP2C9 and 3 moreextracellular space, cytosol

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP2C8 and 5 moreextracellular space, cytosol

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP2C9, CYP2J2extracellular space, cytosol

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP2D6 and 4 moreextracellular space, cytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 24 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 24 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1extracellular space, cytosol

a quinoneReach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

Catalysed by ABCC4, SQOR, CYC1, UQCRFS1inner side of the membrane, outer side of the membraneOne of 6 routes

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP3A4, CYP2C9extracellular space, cytosol

prostaglandin J2Reach from here →

solute carrier organic anion transporter (cholate)
transport of GSH and prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

solute carrier organic anion transporter (cholate)
transport of GSH and prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

dopamine 3-O-sulfateReach from here →

solute carrier organic anion transporter (cholate)
transport of dopamine and GSH (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SLCO1A2, SLCO1B3, SULT1B1, SULT1A3 and 2 moreextracellular space, cytosol

dopamine 4-O-sulfateReach from here →

solute carrier organic anion transporter (cholate)
transport of dopamine and GSH (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by SLCO1A2, SLCO1B3, SULT1A3, SULT1A1extracellular space, cytosolOne of 2 routes

hyocholateReach from here →

solute carrier organic anion transporter (cholate)
solute carrier organic anion transporter (chenodiol)
Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
glutathione = L-cysteinylglycine + 5-oxo-L-proline
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by ABCC4, CHAC2, CHAC1, GGACTinner side of the membrane, outer side of the membrane

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1A2, SLCO1B3, ALOX15extracellular space, cytosol

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by SLCO1A2, SLCO1B3, ALOX15extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by SLCO1A2, SLCO1B3, PM20D1extracellular space, cytosol

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 24 moreextracellular space, cytosolOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 24 moreextracellular space, cytosolOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1A2, SLCO1B3, CYP2C9extracellular space, cytosol

chenodeoxycholoyl-24-O-(beta-D-glucuronate)Reach from here →

solute carrier organic anion transporter (cholate)
solute carrier organic anion transporter (chenodiol)
chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Catalysed by SLCO1A2, SLCO1B3, UGT2A2, UGT1A3extracellular space, cytosol

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

solute carrier organic anion transporter (cholate)
transport of arachidonate and GSH (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1A2, SLCO1B3, CYP1A1, CYP1A2 and 24 moreextracellular space, cytosol

(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by ABCC4, PTGES, MGST3, GPX1 and 4 moreinner side of the membrane, outer side of the membrane

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

solute carrier organic anion transporter (cholate)
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by SLCO1A2, SLCO1B3, GGTLC3, GGT1 and 5 moreextracellular space, cytosol

an organic moleculeReach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by ABCC4, CP, PRDX6, CYP2D7 and 24 moreinner side of the membrane, outer side of the membrane

beta-D-glucosyl-(1->3)-O-chenodeoxycholateReach from here →

solute carrier organic anion transporter (cholate)
solute carrier organic anion transporter (chenodiol)
a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)

Catalysed by SLCO1A2, SLCO1B3, GBA2extracellular space, cytosolOne of 2 routes

N-octanoyl-(2S)-hydroxyglycineReach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O