O-phosphoethanolamine

Three steps

• fatty acidReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. phosphatidylethanolamine 2-acylhydrolase

  Catalysed by PCYT2, SELENOI, CEPT1, PLA2G10 and 17 morecytosolOne of 2 routes

• (S)-lactic acidReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. transport of acetate and L-lactate (cytosol to extracellular)

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 7 morecytosol, extracellular spaceOne of 2 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• N-(2-hydroxytetracosanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. 2-hydroxytetracosanoyl-CoA + sphinganine = N-(2-hydroxytetracosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3 and 1 morecytosol

• N-tetracosanoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3 and 2 morecytosol

• N-hexacosanoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3 and 2 morecytosol

• 2-deoxy-alpha-D-ribose 1-phosphateReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  3. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

  Catalysed by ETNPPL, DERA, PGM2cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by PCYT2, SELENOI, CEPT1, PTDSS1 and 1 morecytosol

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, SELENOI, CEPT1, PLA2G4E and 2 morecytosol

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. Phosphoethanolamine phosphohydrolase
  2. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
  3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

  Catalysed by PHOSPHO1, ENPP2cytosol

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, SELENOI, CEPT1, PLAAT5 and 1 morecytosol

• N-acetylputrescineReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• N(8)-acetylspermidineReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. Acetaldehyde:NAD+ oxidoreductase
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by ETNPPL, ALDH3A1, ALDH3B1, ALDH1A3 and 2 morecytosol

• D-glyceraldehyde 3-phosphateReach from here →
  1. ethanolamine-phosphate phosphate-lyase (deaminating
  2. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
  3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

  Catalysed by ETNPPL, DERAcytosol

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, SELENOI, CEPT1, PLA2G4E and 2 morecytosolOne of 2 routes

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine

  Catalysed by PCYT2, SELENOI, CEPT1, PLA2G15cytosolOne of 2 routes

• hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by PCYT2, CEPT1, PLAAT3, PLAAT1cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by PCYT2, SELENOI, CEPT1, PEMTcytosol

• a 2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)

  Catalysed by PCYT2, SELENOI, CEPT1, DDHD1cytosolOne of 2 routes

• N-docosanoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3 and 2 morecytosol

• N-(2-hydroxydocosanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. 2-hydroxydocosanoyl-CoA + sphinganine = N-(2-hydroxydocosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3 and 1 morecytosol

• N-eicosanoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS1 and 2 morecytosol

• N-(octadecanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS1 and 5 morecytosol

• N-(2-hydroxyoctadecanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. 2-hydroxyoctadecanoyl-CoA + sphinganine = N-(2-hydroxyoctadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS1 and 1 morecytosol

• N-hexadecanoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS6 and 2 morecytosol

• N-(2-hydroxyhexadecanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. 2-hydroxyhexadecanoyl-CoA + sphinganine = N-(2-hydroxyhexadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS5cytosol

• N-(tetradecanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS6 and 1 morecytosol

• N-(octacosanoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. octacosanoyl-CoA + sphinganine = N-(octacosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS3cytosol

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, CEPT1, PLAAT5, PLAAT2cytosolOne of 3 routes

• 1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

  Catalysed by PCYT2, CEPT1, PLA2G15cytosolOne of 2 routes

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PCYT2, SELENOI, CEPT1, SGMS1 and 2 morecytosol

• N-(9Z-octadecenoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS5 and 1 morecytosol

• N-(15Z-tetracosenoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS2cytosol

• an N-tetracosenoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. tetracosenoyl-CoA + sphinganine = an N-tetracosenoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS2cytosol

• N-hexacosenoylsphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. hexacosenoyl-CoA + sphinganine = N-hexacosenoylsphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS2cytosol

• N-(2-hydroxytetracosenoyl)-sphinganineReach from here →
  1. Sphinganine-1-phosphate pamlmitaldehyde-lyase
  2. sphinganine 1-phosphate + H2O = sphinganine + phosphate
  3. 2-hydroxytetracosenoyl-CoA + sphinganine = N-(2-hydroxytetracosenoyl)-sphinganine + CoA + H(+)

  Catalysed by SGPL1, SGPP2, SGPP1, CERS2cytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by PCYT2, CEPT1, PTDSS2cytosol

• 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

  Catalysed by PCYT2, CEPT1, PLA2G15cytosol

• 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoateReach from here →
  1. Phosphoethanolamine phosphohydrolase
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PHOSPHO1, FAAH, PLA2G15cytosol

• 2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by PCYT2, CEPT1, PLA2G4Ecytosol

• 1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by PCYT2, CEPT1, PLA2G15cytosol

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, CEPT1, PLA2G4E, PLAAT5 and 1 morecytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PCYT2, CEPT1, PLA2G4Ecytosol

• (9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Phosphoethanolamine phosphohydrolase
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PHOSPHO1, FAAH, PLA2G15cytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by PCYT2, CEPT1, PLA2G4EcytosolOne of 3 routes

• N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by PCYT2, CEPT1, PLAAT3, PLAAT1cytosolOne of 4 routes

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PCYT2, SELENOI, CEPT1, SGMS2 and 1 morecytosol

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. CTP:ethanolamine-phosphate cytidylyltransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PCYT2, SELENOI, CEPT1, SGMS2 and 1 morecytosol