phosphatidic acid

Three steps

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. ATP:acylglycerol 3-phosphotransferase

  Catalysed by DGKI, DGKZ, LIPF, LIPC and 14 morenucleus, extracellular space, cytosolOne of 6 routes

• a cholesterol esterReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by DGKI, DGKZ, CHPT1, CEPT1 and 1 morenucleus, cytosolOne of 2 routes

• anilineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 5 morenucleus, cytosol

• CHEBI:17312Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 3 morenucleus, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by DGKI, DGKZ, CHPT1, CEPT1 and 18 morenucleus, cytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 4 morenucleus, cytosol, mitochondrial matrix

• a sphingomyelinReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by DGKI, DGKZ, CHPT1, CEPT1 and 2 morenucleus, cytosol, Golgi apparatusOne of 13 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrix

• glycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

  Catalysed by DGKI, DGKZ, LIPF, LIPC and 13 morenucleus, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 3 morenucleus, cytosol

• a diacylglycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 22 morenucleus, cytosolOne of 2 routes

• dodecanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• phosphatidyl-L-serineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
  3. L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase

  Catalysed by DGKI, DGKZ, SELENOI, CEPT1 and 1 morenucleus, cytosolOne of 2 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus, cytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleusOne of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 2 morenucleusOne of 2 routes

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleusOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 11 morenucleus, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 11 morenucleus, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• octadecanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• alpha-linolenic acidReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• CHEBI:27540Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 9 morenucleus, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 17 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• CHEBI:28701Reach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, peroxisomeOne of 7 routes

• phosphocholineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus

• tetradecanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• hexacosanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• eicosanoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• (15Z)-tetracosenoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. 1,2-diacyl-sn-glycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by DGKI, DGKZ, LPLnucleus, extracellular spaceOne of 12 routes

• a fatty aldehydeReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
  3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

  Catalysed by DGKI, DGKZ, DAGLB, ABHD11 and 2 morenucleus

• a sterol esterReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleus

• a 1,3-diacylglycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 5 morenucleus, cytosolOne of 5 routes

• a 1,2-diacylglycerolReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 7 morenucleus, cytosolOne of 6 routes

• taurineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 4 morenucleus, cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline

  Catalysed by DGKI, DGKZ, SGMS1, SGMS2 and 1 morenucleusOne of 2 routes

• glycineReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 6 morenucleus, cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Diacylglycerol Phosphate Kinase (Homo Sapiens)
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by DGKI, DGKZ, DGAT1, MOGAT2 and 4 morenucleus, cytosol, mitochondrial matrixOne of 2 routes