N-(4-oxoglutaryl)-L-cysteinylglycine

Three steps

• glutathione disulfideReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 12 morecytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• L-tyrosineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosolOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-oxo-L-prolineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by NIT1, CHAC2, CHAC1

• histamineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• S-sulfanylglutathioneReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, mitochondrial matrixOne of 5 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosolOne of 4 routes

• dopamineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• L-prolineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• N-benzoylglycineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by NIT1, ANPEP, LAP3, NPEPPScytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosolOne of 2 routes

• ubiquinol-10Reach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by NIT1, CHAC2, CHAC1, SQOR

• Mo-molybdopterinReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol

• (R)-noradrenalineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• (2S)-2-aminobutanoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosolOne of 2 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 2 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by NIT1, CHAC2, CHAC1, GPX1 and 1 more

• ursodeoxycholateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 5 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 2 routes

• thio-Mo-molybdopterinReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• glycodeoxycholateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by NIT1, ANPEP, LAP3, NPEPPScytosolOne of 3 routes

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by NIT1, CHAC2, CHAC1, GPX1 and 2 more

• N-tetradecanoylglycineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• N-eicosanoylglycinateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• N-docosanoylglycineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• N-hexacosanoylglycineReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. L-cysteinylglycine dipeptidase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by NIT1, ANPEP, LAP3, NPEPPS and 1 morecytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by NIT1, CHAC2, CHAC1, PTGES and 5 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by NIT1, CHAC2, CHAC1, GPX1 and 1 more

• thromboxane B2Reach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 4 morecytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by NIT1, CHAC2, CHAC1, GSTT4 and 22 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by NIT1, CHAC2, CHAC1, GPX1 and 3 more

• taurochenodeoxycholateReach from here →
  1. N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate
  2. gamma-glutamyltransferase (alanine)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by NIT1, GGTLC3, GGT1, GGT5 and 6 morecytosol, extracellular spaceOne of 3 routes