2,4-dinitrophenyl-S-glutathione

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX12Bextracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. Arachidonate:oxygen 8-oxidoreductase

Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 2 routes

1. transport of arachidonate (cytosol to extracellular)
2. fatty acid amide hydrolase (arachidonate)

Catalysed by SLCO1B1, FAAHextracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2C9 and 2 moreextracellular space, cytosol

1. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
2. 10-HETE[n] + NAD+[n] = H+[n] + NADH[n] + 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate[n]

Catalysed by SLCO1B1, ADH4extracellular space, cytosol, nucleusOne of 3 routes

1. solute carrier organic anion transporter (chenodiol)
2. chenodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

Catalysed by SLCO1A2, SLCO1B3, HSD17B10extracellular space, cytosolOne of 2 routes

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

Catalysed by SLCO1B1, PTGS2extracellular space, cytosolOne of 2 routes

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Catalysed by SLCO1B1, PTGS2extracellular space, cytosolOne of 2 routes

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1B1, PTGS2extracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. Arachidonate: oxygen 11-oxidoreductase

Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 2 routes

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 24 moreextracellular space, cytosolOne of 4 routes

1. transport of arachidonate (cytosol to extracellular)
2. unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 3 routes

1. transport of arachidonate (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Catalysed by SLCO1B1, ABHD16Aextracellular space, cytosol

1. transport of prostaglandin D2 (cytosol to extracellular)
2. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Catalysed by SLCO1B1, AKR1C3, AKR1C2extracellular space, cytosol

1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
2. dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP3A7extracellular space, cytosol

1. transport of prostaglandin H2 (cytosol to extracellular)
2. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Catalysed by SLCO1B1, TBXAS1, CYP2S1, PTGES2extracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP4F8extracellular space, cytosol

1. transport of prostaglandin E1 (cytosol to extracellular)
2. prostaglandin-E synthase (prostaglandin E1)

Catalysed by SLCO1B1, PTGES, PTGES3, PTGES2extracellular space, cytosolOne of 2 routes

1. transport of prostaglandin H2 (cytosol to extracellular)
2. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP4F8extracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15Bextracellular space, cytosol

1. transport of arachidonate (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15Bextracellular space, cytosol

1. transport of acetylcholine (cytosol to extracellular)
2. Acetylcholine aectylhydrolase
3. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)

Catalysed by SLCO1B3, BCHE, ACHE, SLC16A4 and 3 moreextracellular space, cytosolOne of 4 routes

1. transport of leukotriene C4 (cytosol to extracellular)
2. leukotriene C4 hydrolysis
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine