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Proteins/UNIPROT:Q7RTT9
Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs. Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations. Functions as a Na(+)- and Cl(-)-independent bidirectional transporter. Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure. Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system. Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney. Also transports guanidine..
Function from UniProtKB (Q7RTT9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
41 statements
41 statements · 5 reference databases · Subject: SLC29A4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
21 reactions
Transported by SLC29A1 or SLC29A4 or SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05032CC BY 4.0Reference data
(R)-noradrenaline(R)-noradrenaline
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
5 names
Resolves to: SLC29A4
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06243CC BY 4.0Reference data
Transported by SLC22A2 or SLC22A3 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06732CC BY 4.0Reference data
dopamine+protondopamine+proton
Transported by SLC29A4
Reaction pageLeft to rightBalancedcytosol, mitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR07760CC BY 4.0Reference data
Transported by SLC29A4
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR07761CC BY 4.0Reference data
Transported by SLC22A2 or SLC29A4 or SLC22A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09192CC BY 4.0Reference data
dopamine+protondopamine+proton
Transported by SLC29A4
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09878CC BY 4.0Reference data
proton+serotoninproton+serotonin
Transported by SLC29A4
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09905CC BY 4.0Reference data
adenosine+protonadenosine+proton
Transported by SLC29A4 or SLC28A3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11395CC BY 4.0Reference data
proton+MAM03099cproton+MAM03099e
Transported by SLC29A4
Reaction pageReversibleBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11788CC BY 4.0Reference data
proton+tryptamineproton+tryptamine
Transported by SLC29A4
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11789CC BY 4.0Reference data