TYSND1 cleaves peroxisomal proteins

After proteins are imported into the peroxisome a subset of proteins are cleaved by the protease TYSND1. Based onmutagenesis of human TYSND1 and the homolog in Arabidopsis, TYSND1 appears to be a trypsin-like serine protease containing a conserved histidine aspartate serine triad essential for catalysis. Mice lacking Tysnd1 have reduced peroxisomal localization of some peroxisomal enzymes and exhibit reduced beta-oxidation of fatty acids and metabolism of phytanic acid. Male mice lacking Tysnd1 are sterile due to sperm that lack acrosomal caps.

Summary from Reactome (R-HSA-9033500), read 2026-09-23.