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Proteins/UNIPROT:Q9BPW9
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Also plays a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH..
Function from UniProtKB (Q9BPW9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
28 statements
28 statements · 5 reference databases · Subject: DHRS9 · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300cytosol
Human-GEM MAR06630CC BY 4.0Reference data
12 names
Resolves to: DHRS9
Reaction pageLeft to rightBalancedEC 1.1.1.300endoplasmic reticulum
Human-GEM MAR06632CC BY 4.0Reference data
androsterone+NAD(1-)5alpha-androstan-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or RDH5 or DHRS9
Reaction pageReversibleBalanced
Rhea RHEA:20381CC BY 4.0Reference data
all-trans-retinol+NAD(1-)all-trans-retinal+NADH(2-)+hydron
Catalysed by DHRS7C or HSD17B6 or RDH16 or ADH1B or ADH4 or ADH7 or HSD17B13 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:21284CC BY 4.0Reference data
3alpha-hydroxy-5alpha-pregnan-20-one+NAD(1-)5alpha-pregnane-3,20-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or HSD17B10 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:41980CC BY 4.0Reference data
CHEBI:11909+NAD(1-)5alpha-pregnane-3,20-dione+NADH(2-)+hydron
Catalysed by DHRS9
Reaction pageDirection not assertedBalanced
Rhea RHEA:41988CC BY 4.0Reference data
17beta-hydroxy-5alpha-androstan-3-one+NAD(1-)5alpha-androstan-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B2 or HSD17B8 or HSD17B10 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:41992CC BY 4.0Reference data
5alpha-androstane-3alpha,17beta-diol+NAD(1-)17beta-hydroxy-5alpha-androstan-3-one+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or AKR1C4 or AKR1C3 or AKR1C2 or AKR1C1 or RDH5 or HSD17B10 or DHRS9
Reaction pageRight to leftBalanced
Rhea RHEA:42004CC BY 4.0Reference data