Proteins/UNIPROT:O43432

EIF4G3

ProteinUNIPROT:O43432

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Functional homolog of EIF4G1..

Function from UniProtKB (O43432), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

28 statements

28 statements · 4 reference databases · Subject: EIF4G3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ADGRV1 covaries with EIF4G3ProteinHetionet hetionet:covaries:84059-8672Inferred only
CAMK1 interacts with EIF4G3ProteinHetionet hetionet:interacts:8536-8672Inferred only
EIF4A1 interacts with EIF4G3ProteinHetionet hetionet:interacts:1973-8672Inferred only
EIF4E interacts with EIF4G3ProteinHetionet hetionet:interacts:1977-8672Inferred only
MKNK1 interacts with EIF4G3ProteinHetionet hetionet:interacts:8569-8672Inferred only
NCBP1 interacts with EIF4G3ProteinHetionet hetionet:interacts:4686-8672Inferred only
EIF4G3 interacts with PABPC1ProteinHetionet hetionet:interacts:26986-8672Inferred only
VAV2 interacts with EIF4G3ProteinHetionet hetionet:interacts:7410-8672Inferred only
EIF4G3 participates in Antimicrobial mechanism of IFN-stimulated genesPathwayReactome R-HSA-1169410Inferred only
EIF4G3 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
EIF4G3 participates in Dengue Virus Genome Translation and ReplicationPathwayReactome R-HSA-9918487Inferred only
EIF4G3 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only

Show the remaining 16

EIF4G3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
EIF4G3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
EIF4G3 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
EIF4G3 participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
EIF4G3 participates in ISG15 antiviral mechanismPathwayReactome R-HSA-1169408Inferred only
EIF4G3 participates in Translation factorsPathwayWikiPathways WP107Inferred only
EIF4G3 participates in Translation inhibitors in chronically activated PDGFRA cellsPathwayWikiPathways WP4566Inferred only
EIF4G3 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
EIF4G3 regulates positive regulation of translationBiological processgene ontology O43432|GO:0045727Inferred only
EIF4G3 regulates regulation of translational initiationBiological processgene ontology O43432|GO:0006446Inferred only
C2CD2L increases the expression of EIF4G3ProteinHetionet hetionet:regulates:9854-8672Inferred only
CDKN1A decreases the expression of EIF4G3ProteinHetionet hetionet:regulates:1026-8672Inferred only
FOSL2 increases the expression of EIF4G3ProteinHetionet hetionet:regulates:2355-8672Inferred only
GNPDA1 increases the expression of EIF4G3ProteinHetionet hetionet:regulates:10007-8672Inferred only
HK1 increases the expression of EIF4G3ProteinHetionet hetionet:regulates:3098-8672Inferred only
NRAS increases the expression of EIF4G3ProteinHetionet hetionet:regulates:4893-8672Inferred only

Other names

5 names

Resolves to: EIF4G3

Also called: eIF-4-gamma 3eIF-4-gamma IIeIF-4G 3eIF4G 3eIF4GII

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