Loading the page.
Proteins/UNIPROT:P49591
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA..
Function from UniProtKB (P49591), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
292 statements
292 statements · 5 reference databases · Subject: SARS1 · Sources: Bgee, gene ontology, Hetionet, Reactome, WikiPathways
3 reactions
ATP+L-seryl residue+MAM03078cAMP+MAM02416c+diphosphate(3-)
Catalysed by SARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.11cytosol
Human-GEM MAR05147CC BY 4.0Reference data
CHEBI:78442+L-seryl residue+ATP(4-)CHEBI:78533+AMP+diphosphate(3-)+
5 names
Resolves to: SARS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12292CC BY 4.0Reference data
CHEBI:78442+L-seryl residue+ATP(4-)CHEBI:78533+AMP+diphosphate(3-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42580CC BY 4.0Reference data