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Proteins/UNIPROT:Q5JU85
Is a guanine nucleotide exchange factor (GEF) for small GTPases of the ARF family, promoting activation of specific ARFs through exchange of GDP for GTP. In vitro, it has GEF activity towards ARF1 and ARF6. Is involved in the regulation of synaptic transmission and plasticity, controlling trafficking and removal of AMPA receptors GRIA2/GLUA2 and GRIA3/GLUA3 at synapses. Additionally, it may regulate the assembly of the post-synaptic density in a Ca(2+)-dependent manner, operating independently of its GEF activity..
Function from UniProtKB (Q5JU85), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
61 statements
61 statements · 2 reference databases · Subject: IQSEC2 · Sources: gene ontology, Hetionet
4 names
Resolves to: IQSEC2