Proteins/UNIPROT:Q9Y566

SHANK1

ProteinUNIPROT:Q9Y566

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Function from UniProtKB (Q9Y566), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autism has a germline basis in SHANK1DiseaseGenCC HGNC:15474|MONDO:0005260Inferred only
complex neurodevelopmental disorder has a germline basis in SHANK1DiseaseGenCC HGNC:15474|MONDO:0100038Inferred only
neurodevelopmental disorder has a germline basis in SHANK1DiseaseGenCC HGNC:15474|MONDO:0700092Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: SHANK1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ABCA1 interacts with SHANK1ProteinHetionet hetionet:interacts:19-50944Inferred only
ADGRB2 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-576Inferred only
ADGRL1 interacts with SHANK1ProteinHetionet hetionet:interacts:22859-50944Inferred only
ADGRL2 interacts with SHANK1ProteinHetionet hetionet:interacts:23266-50944Inferred only
ARHGEF7 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-8874Inferred only
BAIAP2 interacts with SHANK1ProteinHetionet hetionet:interacts:10458-50944Inferred only
SHANK1 interacts with BAIAP2L1ProteinHetionet hetionet:interacts:50944-55971Inferred only
DLG4 interacts with SHANK1ProteinHetionet hetionet:interacts:1742-50944Inferred only
DLGAP1 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-9229Inferred only
DNM2 interacts with SHANK1ProteinHetionet hetionet:interacts:1785-50944Inferred only
HOMER1 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-9456Inferred only
RPS6KA2 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-6196Inferred only

Show the remaining 16

RPS6KA3 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-6197Inferred only
SHANK1 interacts with SHARPINProteinHetionet hetionet:interacts:50944-81858Inferred only
SPTAN1 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-6709Inferred only
SSTR2 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-6752Inferred only
STAT1 interacts with SHANK1ProteinHetionet hetionet:interacts:50944-6772Inferred only
SHANK1 interacts with TANC1ProteinHetionet hetionet:interacts:50944-85461Inferred only
SHANK1 participates in 15q25 copy number variationPathwayWikiPathways WP5408Inferred only
SHANK1 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
SHANK1 participates in Disruption of postsynaptic signaling by CNVPathwayWikiPathways WP4875Inferred only
SHANK1 participates in Fragile X syndromePathwayWikiPathways WP4549Inferred only
SHANK1 participates in Neurexins and neuroliginsPathwayReactome R-HSA-6794361Inferred only
SHANK1 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
SHANK1 participates in Protein-protein interactions at synapsesPathwayReactome R-HSA-6794362Inferred only
SHANK1 regulates negative regulation of actin filament bundle assemblyBiological processgene ontology Q9Y566|GO:0032232Inferred only
SHANK1 regulates positive regulation of dendritic spine developmentBiological processgene ontology Q9Y566|GO:0060999Inferred only
SHANK1 regulates positive regulation of excitatory postsynaptic potentialBiological processgene ontology Q9Y566|GO:2000463Inferred only

Other names

3 names

Resolves to: SHANK1

Also called: Somatostatin receptor-interacting proteinSSTR-interacting proteinSSTRIP

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