Proteins/UNIPROT:P16109

SELP

ProteinUNIPROT:P16109

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3)..

Function from UniProtKB (P16109), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 4 reference databases · Subject: SELP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

BACE2 covaries with SELPProteinHetionet hetionet:covaries:25825-6403Inferred only
SELP covaries with GPATCH4ProteinHetionet hetionet:covaries:54865-6403Inferred only
IL2 covaries with SELPProteinHetionet hetionet:covaries:3558-6403Inferred only
MAGIX covaries with SELPProteinHetionet hetionet:covaries:6403-79917Inferred only
TSPAN4 covaries with SELPProteinHetionet hetionet:covaries:6403-7106Inferred only
ZNF623 covaries with SELPProteinHetionet hetionet:covaries:6403-9831Inferred only
SELP interacts with AP1M1ProteinHetionet hetionet:interacts:6403-8907Inferred only
SELP interacts with CD24ProteinHetionet hetionet:interacts:100133941-6403Inferred only
SELP interacts with EZRProteinHetionet hetionet:interacts:6403-7430Inferred only
FUT4 interacts with SELPProteinHetionet hetionet:interacts:2526-6403Inferred only
GP1BA interacts with SELPProteinHetionet hetionet:interacts:2811-6403Inferred only
SELP interacts with SELPLGProteinHetionet hetionet:interacts:6403-6404Inferred only

Show the remaining 17

SERPING1 interacts with SELPProteinHetionet hetionet:interacts:6403-710Inferred only
SELP interacts with SNX17ProteinHetionet hetionet:interacts:6403-9784Inferred only
VCAN interacts with SELPProteinHetionet hetionet:interacts:1462-6403Inferred only
SELP participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
SELP participates in Cells and molecules involved in local acute inflammatory response PathwayWikiPathways WP4493Inferred only
SELP participates in Complement systemPathwayWikiPathways WP2806Inferred only
SELP participates in HemostasisPathwayReactome R-HSA-109582Inferred only
SELP participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
SELP participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
SELP participates in Platelet degranulationPathwayReactome R-HSA-114608Inferred only
SELP participates in Platelet mediated interactions with vascular and circulating cellsPathwayWikiPathways WP4462Inferred only
SELP participates in Response to elevated platelet cytosolic Ca2+PathwayReactome R-HSA-76005Inferred only
SELP participates in Spinal cord injuryPathwayWikiPathways WP2431Inferred only
SELP regulates positive regulation of leukocyte tethering or rollingBiological processgene ontology P16109|GO:1903238Inferred only
SELP regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P16109|GO:0051897Inferred only
SELP regulates positive regulation of platelet activationBiological processgene ontology P16109|GO:0010572Inferred only
SELP regulates regulation of integrin activationBiological processgene ontology P16109|GO:0033623Inferred only

Other names

10 names

Resolves to: SELP

Also called: CD antigen CD62PCD62 antigen-like family member PGMP-140GMRPGranule membrane protein 140GRMPLECAM3Leukocyte-endothelial cell adhesion molecule 3PADGEMPlatelet activation dependent granule-external membrane protein

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