Proteins/UNIPROT:Q8N6Q3

CD177

ProteinUNIPROT:Q8N6Q3

In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis..

Function from UniProtKB (Q8N6Q3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 3 reference databases · Subject: CD177 · Sources: gene ontology, Hetionet, Reactome

Order

IL16 covaries with CD177ProteinHetionet hetionet:covaries:3603-57126Inferred only
EWSR1 interacts with CD177ProteinHetionet hetionet:interacts:2130-57126Inferred only
KCNIP3 interacts with CD177ProteinHetionet hetionet:interacts:30818-57126Inferred only
SHBG interacts with CD177ProteinHetionet hetionet:interacts:57126-6462Inferred only
CD177 participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
CD177 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
CD177 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
CD177 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CD177 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CD177 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
CD177 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
CD177 regulates positive regulation of neutrophil degranulationBiological processgene ontology Q8N6Q3|GO:0043315Inferred only

Show the remaining 3

CD177 regulates positive regulation of superoxide anion generationBiological processgene ontology Q8N6Q3|GO:0032930Inferred only
CD177 regulates regulation of endocytosisBiological processgene ontology Q8N6Q3|GO:0030100Inferred only
CD177 regulates regulation of integrin-mediated signaling pathwayBiological processgene ontology Q8N6Q3|GO:2001044Inferred only

Other names

9 names

Resolves to: CD177

Also called: CD antigen CD177HNA-2aHuman neutrophil alloantigen 2aNB1NB1 glycoproteinNB1 GPPolycythemia rubra vera protein 1PRV-1PRV1

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