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Proteins/UNIPROT:P08648
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. ITGA5:ITGB1 acts as a receptor for SNED1 and mediates R-G-D-dependent cell adhesion to SNED1..
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus..
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19..
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions..
Function from UniProtKB (P08648), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
86 statements
86 statements · 4 reference databases · Subject: ITGA5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
7 names
Resolves to: ITGA5