Proteins/UNIPROT:P01591

JCHAIN

ProteinUNIPROT:P01591

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component..

Function from UniProtKB (P01591), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: JCHAIN · Sources: gene ontology, Hetionet, Reactome

Order

JCHAIN covaries with TRIM6-TRIM34ProteinHetionet hetionet:covaries:3512-445372Inferred only
CD79A interacts with JCHAINProteinHetionet hetionet:interacts:3512-973Inferred only
JCHAIN interacts with UBCProteinHetionet hetionet:interacts:3512-7316Inferred only
JCHAIN participates in Binding and Uptake of Ligands by Scavenger ReceptorsPathwayReactome R-HSA-2173782Inferred only
JCHAIN participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
JCHAIN participates in HemostasisPathwayReactome R-HSA-109582Inferred only
JCHAIN participates in Scavenging of heme from plasmaPathwayReactome R-HSA-2168880Inferred only
JCHAIN participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
JCHAIN regulates positive regulation of respiratory burstBiological processgene ontology P01591|GO:0060267Inferred only

Other names

4 names

Resolves to: JCHAIN

Also called: IGCJIGJImmunoglobulin J chainJoining chain of multimeric IgA and IgM

← Every protein Find it in the graph →