Proteins/UNIPROT:P06729

CD2

ProteinUNIPROT:P06729

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Function from UniProtKB (P06729), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

36 statements

36 statements · 4 reference databases · Subject: CD2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

AMER2 covaries with CD2ProteinHetionet hetionet:covaries:219287-914Inferred only
LCE2C covaries with CD2ProteinHetionet hetionet:covaries:353140-914Inferred only
XKR5 covaries with CD2ProteinHetionet hetionet:covaries:389610-914Inferred only
CD2 interacts with CD2APProteinHetionet hetionet:interacts:23607-914Inferred only
CD2 interacts with CD2BP2ProteinHetionet hetionet:interacts:10421-914Inferred only
CD2 interacts with CD4ProteinHetionet hetionet:interacts:914-920Inferred only
CD2 interacts with CD48ProteinHetionet hetionet:interacts:914-962Inferred only
CD2 interacts with CD5ProteinHetionet hetionet:interacts:914-921Inferred only
CD2 interacts with CD53ProteinHetionet hetionet:interacts:914-963Inferred only
CD2 interacts with CD58ProteinHetionet hetionet:interacts:914-965Inferred only
CD2 interacts with CD59ProteinHetionet hetionet:interacts:914-966Inferred only
CD2 interacts with EP300ProteinHetionet hetionet:interacts:2033-914Inferred only

Show the remaining 24

CD2 interacts with FYNProteinHetionet hetionet:interacts:2534-914Inferred only
CD2 interacts with GIGYF2ProteinHetionet hetionet:interacts:26058-914Inferred only
CD2 interacts with ITKProteinHetionet hetionet:interacts:3702-914Inferred only
CD2 interacts with LCKProteinHetionet hetionet:interacts:3932-914Inferred only
CD2 interacts with LGALS1ProteinHetionet hetionet:interacts:3956-914Inferred only
CD2 interacts with LYARProteinHetionet hetionet:interacts:55646-914Inferred only
CD2 interacts with MXD1ProteinHetionet hetionet:interacts:4084-914Inferred only
CD2 interacts with PSTPIP1ProteinHetionet hetionet:interacts:9051-914Inferred only
CD2 interacts with PTPRCProteinHetionet hetionet:interacts:5788-914Inferred only
CD2 interacts with SH3KBP1ProteinHetionet hetionet:interacts:30011-914Inferred only
CD2 interacts with SP1ProteinHetionet hetionet:interacts:6667-914Inferred only
CD2 interacts with UBCProteinHetionet hetionet:interacts:7316-914Inferred only
CD2 participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
CD2 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
CD2 participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
CD2 participates in Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complexPathwayWikiPathways WP4884Inferred only
CD2 regulates positive regulation of interleukin-8 productionBiological processgene ontology P06729|GO:0032757Inferred only
CD2 regulates positive regulation of myeloid dendritic cell activationBiological processgene ontology P06729|GO:0030887Inferred only
CD2 regulates positive regulation of tumor necrosis factor productionBiological processgene ontology P06729|GO:0032760Inferred only
CD2 regulates positive regulation of type II interferon productionBiological processgene ontology P06729|GO:0032729Inferred only
CD2 regulates regulation of T cell differentiationBiological processgene ontology P06729|GO:0045580Inferred only
CD2 decreases the expression of GDF15ProteinHetionet hetionet:regulates:914-9518Inferred only
CD2 decreases the expression of RPIAProteinHetionet hetionet:regulates:914-22934Inferred only
CD2 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:914-6192Inferred only

Other names

7 names

Resolves to: CD2

Also called: CD antigen CD2Erythrocyte receptorLFA-2LFA-3 receptorRosette receptorSRBCT-cell surface antigen T11/Leu-5

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