Proteins/UNIPROT:Q14242

SELPLG

ProteinUNIPROT:Q14242

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture..

(Microbial infection) Acts as a receptor for enterovirus 71..

Function from UniProtKB (Q14242), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: SELPLG · Sources: Hetionet, Reactome, WikiPathways

Order

CCDC154 covaries with SELPLGProteinHetionet hetionet:covaries:6404-645811Inferred only
EDN2 covaries with SELPLGProteinHetionet hetionet:covaries:1907-6404Inferred only
GLTPD2 covaries with SELPLGProteinHetionet hetionet:covaries:388323-6404Inferred only
HMHB1 covaries with SELPLGProteinHetionet hetionet:covaries:57824-6404Inferred only
SLX4 covaries with SELPLGProteinHetionet hetionet:covaries:6404-84464Inferred only
ZFYVE19 covaries with SELPLGProteinHetionet hetionet:covaries:6404-84936Inferred only
MSN interacts with SELPLGProteinHetionet hetionet:interacts:4478-6404Inferred only
SELP interacts with SELPLGProteinHetionet hetionet:interacts:6403-6404Inferred only
SELPLG interacts with SNX20ProteinHetionet hetionet:interacts:124460-6404Inferred only
SELPLG interacts with TNIP1ProteinHetionet hetionet:interacts:10318-6404Inferred only
SELPLG participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
SELPLG participates in Cells and molecules involved in local acute inflammatory response PathwayWikiPathways WP4493Inferred only

Show the remaining 7

SELPLG participates in Complement systemPathwayWikiPathways WP2806Inferred only
SELPLG participates in HemostasisPathwayReactome R-HSA-109582Inferred only
SELPLG participates in Platelet mediated interactions with vascular and circulating cellsPathwayWikiPathways WP4462Inferred only
SELPLG participates in Vedolizumab therapy for inflammatory bowel diseasePathwayWikiPathways WP5512Inferred only
GUK1 increases the expression of SELPLGProteinHetionet hetionet:regulates:2987-6404Inferred only
ZFX increases the expression of SELPLGProteinHetionet hetionet:regulates:7543-6404Inferred only
ZNF599 increases the expression of SELPLGProteinHetionet hetionet:regulates:148103-6404Inferred only

Other names

3 names

Resolves to: SELPLG

Also called: CD antigen CD162PSGL-1Selectin P ligand

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