Proteins/UNIPROT:P23229

ITGA6

ProteinUNIPROT:P23229

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling..

Function from UniProtKB (P23229), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

junctional epidermolysis bullosa with pyloric atresia has a germline basis in ITGA6DiseaseGenCC HGNC:6142|MONDO:0009183Inferred only

Statements

64 statements

64 statements · 4 reference databases · Subject: ITGA6 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TAFA5 covaries with ITGA6ProteinHetionet hetionet:covaries:25817-3655Inferred only
TEC covaries with ITGA6ProteinHetionet hetionet:covaries:3655-7006Inferred only
BIN1 interacts with ITGA6ProteinHetionet hetionet:interacts:274-3655Inferred only
CANX interacts with ITGA6ProteinHetionet hetionet:interacts:3655-821Inferred only
CD151 interacts with ITGA6ProteinHetionet hetionet:interacts:3655-977Inferred only
CD36 interacts with ITGA6ProteinHetionet hetionet:interacts:3655-948Inferred only
CD63 interacts with ITGA6ProteinHetionet hetionet:interacts:3655-967Inferred only
ITGA6 interacts with CD82ProteinHetionet hetionet:interacts:3655-3732Inferred only
COL17A1 interacts with ITGA6ProteinHetionet hetionet:interacts:1308-3655Inferred only
ITGA6 interacts with GIPC1ProteinHetionet hetionet:interacts:10755-3655Inferred only
GRB2 interacts with ITGA6ProteinHetionet hetionet:interacts:2885-3655Inferred only
ITGA6 interacts with ITGB1ProteinHetionet hetionet:interacts:3655-3688Inferred only

Show the remaining 52

ITGA6 interacts with ITGB4ProteinHetionet hetionet:interacts:3655-3691Inferred only
ITGA6 interacts with PCSK5ProteinHetionet hetionet:interacts:3655-5125Inferred only
ITGA6 interacts with PLECProteinHetionet hetionet:interacts:3655-5339Inferred only
ITGA6 interacts with PXNProteinHetionet hetionet:interacts:3655-5829Inferred only
ITGA6 interacts with RPSAProteinHetionet hetionet:interacts:3655-3921Inferred only
ITGA6 interacts with TSPAN4ProteinHetionet hetionet:interacts:3655-7106Inferred only
ITGA6 participates in 11p11 2 copy number variation syndrome PathwayWikiPathways WP5348Inferred only
ITGA6 participates in Alpha 6 beta 4 signalingPathwayWikiPathways WP244Inferred only
ITGA6 participates in Apoptosis regulation by parathyroid hormone related proteinPathwayWikiPathways WP3872Inferred only
ITGA6 participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
ITGA6 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
ITGA6 participates in Basigin interactionsPathwayReactome R-HSA-210991Inferred only
ITGA6 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
ITGA6 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
ITGA6 participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
ITGA6 participates in Cell surface interactions at the vascular wallPathwayReactome R-HSA-202733Inferred only
ITGA6 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
ITGA6 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
ITGA6 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ITGA6 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
ITGA6 participates in Developmental Cell Lineages of the Integumentary SystemPathwayReactome R-HSA-9734779Inferred only
ITGA6 participates in Developmental Lineage of Mammary Gland Alveolar CellsPathwayReactome R-HSA-9927426Inferred only
ITGA6 participates in Developmental Lineage of Mammary Gland Luminal Epithelial CellsPathwayReactome R-HSA-9927418Inferred only
ITGA6 participates in Developmental Lineage of Mammary Gland Myoepithelial CellsPathwayReactome R-HSA-9927432Inferred only
ITGA6 participates in Developmental Lineage of Mammary Stem CellsPathwayReactome R-HSA-9938206Inferred only
ITGA6 participates in Developmental Lineages of the Mammary GlandPathwayReactome R-HSA-9924644Inferred only
ITGA6 participates in Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian SkinPathwayReactome R-HSA-9725554Inferred only
ITGA6 participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
ITGA6 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ITGA6 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
ITGA6 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
ITGA6 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
ITGA6 participates in Hippo Merlin signaling dysregulationPathwayWikiPathways WP4541Inferred only
ITGA6 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only
ITGA6 participates in Integrin mediated cell adhesionPathwayWikiPathways WP185Inferred only
ITGA6 participates in Laminin interactionsPathwayReactome R-HSA-3000157Inferred only
ITGA6 participates in Mammary gland development embryonic development stage 1 of 4PathwayWikiPathways WP2813Inferred only
ITGA6 participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
ITGA6 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
ITGA6 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
ITGA6 participates in Small cell lung cancerPathwayWikiPathways WP4658Inferred only
ITGA6 participates in Syndecan interactionsPathwayReactome R-HSA-3000170Inferred only
ITGA6 participates in Type I hemidesmosome assemblyPathwayReactome R-HSA-446107Inferred only
ITGA6 regulates negative regulation of extrinsic apoptotic signaling pathwayBiological processgene ontology P23229|GO:2001237Inferred only
ITGA6 regulates positive regulation of apoptotic processBiological processgene ontology P23229|GO:0043065Inferred only
ITGA6 regulates positive regulation of cell migrationBiological processgene ontology P23229|GO:0030335Inferred only
ITGA6 regulates positive regulation of GTPase activityBiological processgene ontology P23229|GO:0043547Inferred only
ITGA6 regulates positive regulation of neuron projection developmentBiological processgene ontology P23229|GO:0010976Inferred only
ITGA6 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P23229|GO:0045944Inferred only
AXL increases the expression of ITGA6ProteinHetionet hetionet:regulates:558-3655Inferred only
LIG1 increases the expression of ITGA6ProteinHetionet hetionet:regulates:3978-3655Inferred only
TBC1D15 increases the expression of ITGA6ProteinHetionet hetionet:regulates:64786-3655Inferred only

Other names

5 names

Resolves to: ITGA6

Also called: [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6Alpha6pCD antigen CD49fCD49 antigen-like family member FVLA-6

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